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Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus

Damage to the annulus fibrosus (AF), the outer region of the intervertebral disc (IVD), results in an undesirable condition that may accelerate IVD degeneration causing low back pain. Despite intense research interest, attempts to regenerate the IVD have failed so far and no effective strategy has t...

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Detalles Bibliográficos
Autores principales: Tavakoli, Javad, Diwan, Ashish D., Tipper, Joanne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402314/
https://www.ncbi.nlm.nih.gov/pubmed/32664453
http://dx.doi.org/10.3390/ijms21144889
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author Tavakoli, Javad
Diwan, Ashish D.
Tipper, Joanne L.
author_facet Tavakoli, Javad
Diwan, Ashish D.
Tipper, Joanne L.
author_sort Tavakoli, Javad
collection PubMed
description Damage to the annulus fibrosus (AF), the outer region of the intervertebral disc (IVD), results in an undesirable condition that may accelerate IVD degeneration causing low back pain. Despite intense research interest, attempts to regenerate the IVD have failed so far and no effective strategy has translated into a successful clinical outcome. Of particular significance, the failure of strategies to repair the AF has been a major drawback in the regeneration of IVD and nucleus replacement. It is unlikely to secure regenerative mediators (cells, genes, and biomolecules) and artificial nucleus materials after injection with an unsealed AF, as IVD is exposed to significant load and large deformation during daily activities. The AF defects strongly change the mechanical properties of the IVD and activate catabolic routes that are responsible for accelerating IVD degeneration. Therefore, there is a strong need to develop effective therapeutic strategies to prevent or reconstruct AF damage to support operational IVD regenerative strategies and nucleus replacement. By the way of this review, repair and regenerative strategies for AF reconstruction, their current status, challenges ahead, and future outlooks were discussed.
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spelling pubmed-74023142020-08-11 Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus Tavakoli, Javad Diwan, Ashish D. Tipper, Joanne L. Int J Mol Sci Review Damage to the annulus fibrosus (AF), the outer region of the intervertebral disc (IVD), results in an undesirable condition that may accelerate IVD degeneration causing low back pain. Despite intense research interest, attempts to regenerate the IVD have failed so far and no effective strategy has translated into a successful clinical outcome. Of particular significance, the failure of strategies to repair the AF has been a major drawback in the regeneration of IVD and nucleus replacement. It is unlikely to secure regenerative mediators (cells, genes, and biomolecules) and artificial nucleus materials after injection with an unsealed AF, as IVD is exposed to significant load and large deformation during daily activities. The AF defects strongly change the mechanical properties of the IVD and activate catabolic routes that are responsible for accelerating IVD degeneration. Therefore, there is a strong need to develop effective therapeutic strategies to prevent or reconstruct AF damage to support operational IVD regenerative strategies and nucleus replacement. By the way of this review, repair and regenerative strategies for AF reconstruction, their current status, challenges ahead, and future outlooks were discussed. MDPI 2020-07-10 /pmc/articles/PMC7402314/ /pubmed/32664453 http://dx.doi.org/10.3390/ijms21144889 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tavakoli, Javad
Diwan, Ashish D.
Tipper, Joanne L.
Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus
title Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus
title_full Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus
title_fullStr Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus
title_full_unstemmed Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus
title_short Advanced Strategies for the Regeneration of Lumbar Disc Annulus Fibrosus
title_sort advanced strategies for the regeneration of lumbar disc annulus fibrosus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402314/
https://www.ncbi.nlm.nih.gov/pubmed/32664453
http://dx.doi.org/10.3390/ijms21144889
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