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Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch

Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insig...

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Detalles Bibliográficos
Autores principales: Kahremany, Shirin, Hofmann, Lukas, Gruzman, Arie, Cohen, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402353/
https://www.ncbi.nlm.nih.gov/pubmed/32664385
http://dx.doi.org/10.3390/ijms21144883
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author Kahremany, Shirin
Hofmann, Lukas
Gruzman, Arie
Cohen, Guy
author_facet Kahremany, Shirin
Hofmann, Lukas
Gruzman, Arie
Cohen, Guy
author_sort Kahremany, Shirin
collection PubMed
description Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insights into the mechanism of itch mediation and modulation. Hence, it became apparent that pruritus is a complex symptom or disease in itself, which requires particular attention to improve patients’ health. Here, we summarize recent findings in pruritoceptive itch, including how this sensation is triggered and modulated by diverse endogenous and exogenous pruritogens and their receptors. A differentiation between mediating pruritogen and modulating pruritogen seems to be of great advantage to understand and decipher the molecular mechanism of itch perception. Only a comprehensive view on itch sensation will provide a solid basis for targeting this long-neglected adverse sensation accompanying numerous diseases and many drug side effects. Finally, we identify critical aspects of itch perception that require future investigation.
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spelling pubmed-74023532020-08-18 Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch Kahremany, Shirin Hofmann, Lukas Gruzman, Arie Cohen, Guy Int J Mol Sci Review Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insights into the mechanism of itch mediation and modulation. Hence, it became apparent that pruritus is a complex symptom or disease in itself, which requires particular attention to improve patients’ health. Here, we summarize recent findings in pruritoceptive itch, including how this sensation is triggered and modulated by diverse endogenous and exogenous pruritogens and their receptors. A differentiation between mediating pruritogen and modulating pruritogen seems to be of great advantage to understand and decipher the molecular mechanism of itch perception. Only a comprehensive view on itch sensation will provide a solid basis for targeting this long-neglected adverse sensation accompanying numerous diseases and many drug side effects. Finally, we identify critical aspects of itch perception that require future investigation. MDPI 2020-07-10 /pmc/articles/PMC7402353/ /pubmed/32664385 http://dx.doi.org/10.3390/ijms21144883 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kahremany, Shirin
Hofmann, Lukas
Gruzman, Arie
Cohen, Guy
Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
title Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
title_full Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
title_fullStr Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
title_full_unstemmed Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
title_short Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
title_sort advances in understanding the initial steps of pruritoceptive itch: how the itch hits the switch
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402353/
https://www.ncbi.nlm.nih.gov/pubmed/32664385
http://dx.doi.org/10.3390/ijms21144883
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