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Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch
Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insig...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402353/ https://www.ncbi.nlm.nih.gov/pubmed/32664385 http://dx.doi.org/10.3390/ijms21144883 |
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author | Kahremany, Shirin Hofmann, Lukas Gruzman, Arie Cohen, Guy |
author_facet | Kahremany, Shirin Hofmann, Lukas Gruzman, Arie Cohen, Guy |
author_sort | Kahremany, Shirin |
collection | PubMed |
description | Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insights into the mechanism of itch mediation and modulation. Hence, it became apparent that pruritus is a complex symptom or disease in itself, which requires particular attention to improve patients’ health. Here, we summarize recent findings in pruritoceptive itch, including how this sensation is triggered and modulated by diverse endogenous and exogenous pruritogens and their receptors. A differentiation between mediating pruritogen and modulating pruritogen seems to be of great advantage to understand and decipher the molecular mechanism of itch perception. Only a comprehensive view on itch sensation will provide a solid basis for targeting this long-neglected adverse sensation accompanying numerous diseases and many drug side effects. Finally, we identify critical aspects of itch perception that require future investigation. |
format | Online Article Text |
id | pubmed-7402353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74023532020-08-18 Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch Kahremany, Shirin Hofmann, Lukas Gruzman, Arie Cohen, Guy Int J Mol Sci Review Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a side effect of drug applications, or a temporary sensation induced by invading pruritogens, as produced by the stinging nettle. Due to extensive research in recent years, it was possible to provide detailed insights into the mechanism of itch mediation and modulation. Hence, it became apparent that pruritus is a complex symptom or disease in itself, which requires particular attention to improve patients’ health. Here, we summarize recent findings in pruritoceptive itch, including how this sensation is triggered and modulated by diverse endogenous and exogenous pruritogens and their receptors. A differentiation between mediating pruritogen and modulating pruritogen seems to be of great advantage to understand and decipher the molecular mechanism of itch perception. Only a comprehensive view on itch sensation will provide a solid basis for targeting this long-neglected adverse sensation accompanying numerous diseases and many drug side effects. Finally, we identify critical aspects of itch perception that require future investigation. MDPI 2020-07-10 /pmc/articles/PMC7402353/ /pubmed/32664385 http://dx.doi.org/10.3390/ijms21144883 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kahremany, Shirin Hofmann, Lukas Gruzman, Arie Cohen, Guy Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch |
title | Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch |
title_full | Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch |
title_fullStr | Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch |
title_full_unstemmed | Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch |
title_short | Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch |
title_sort | advances in understanding the initial steps of pruritoceptive itch: how the itch hits the switch |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402353/ https://www.ncbi.nlm.nih.gov/pubmed/32664385 http://dx.doi.org/10.3390/ijms21144883 |
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