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Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors

Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly studied. However, how the maternal β-catenin activity is suppressed in the nondorsal cells remains poorly understood. Nanog is known to play a central role for maintenance of the...

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Detalles Bibliográficos
Autores principales: He, Mudan, Zhang, Ru, Jiao, Shengbo, Zhang, Fenghua, Ye, Ding, Wang, Houpeng, Sun, Yonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402524/
https://www.ncbi.nlm.nih.gov/pubmed/32702011
http://dx.doi.org/10.1371/journal.pbio.3000561