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An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias

Myelosuppression is one of the most common and severe adverse events associated with anti-cancer therapies and can be a source of drug attrition. Current mathematical modeling methods for assessing cytopenia risk rely on indirect measurements of drug effects and primarily focus on single lineage res...

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Detalles Bibliográficos
Autores principales: Wilson, Jennifer L., Lu, Dan, Corr, Nick, Fullerton, Aaron, Lu, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402526/
https://www.ncbi.nlm.nih.gov/pubmed/32701980
http://dx.doi.org/10.1371/journal.pcbi.1007620

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