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Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection

Atypical hemolytic uremic syndrome (aHUS), defines as non-Shiga toxin HUS, is thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and renal impairment. aHUS is associated with high morbidity and mortality, necessitating the need for an early d...

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Autores principales: Khurshid, Qasim, Mahmoud, Anas, Shahid, Maria, Mohamed, Alaa, Shahbaz, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402547/
https://www.ncbi.nlm.nih.gov/pubmed/32775085
http://dx.doi.org/10.7759/cureus.9005
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author Khurshid, Qasim
Mahmoud, Anas
Shahid, Maria
Mohamed, Alaa
Shahbaz, Amir
author_facet Khurshid, Qasim
Mahmoud, Anas
Shahid, Maria
Mohamed, Alaa
Shahbaz, Amir
author_sort Khurshid, Qasim
collection PubMed
description Atypical hemolytic uremic syndrome (aHUS), defines as non-Shiga toxin HUS, is thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and renal impairment. aHUS is associated with high morbidity and mortality, necessitating the need for an early diagnosis to limit target organ damage. Mutations or autoantibodies against specific complement factors over‐activate the complement system forming microthrombi. aHUS has the potential to cause multi‐organ system dysfunction, but it predominantly affects the kidneys. aHUS is treated with eculizumab, a terminal blocker of the complement system. Clostridium difficile infection is a rare precipitant of aHUS. We present a case of aHUS associated with Clostridium difficile infection in a 60-year-old female patient that was successfully treated with eculizumab.
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spelling pubmed-74025472020-08-06 Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection Khurshid, Qasim Mahmoud, Anas Shahid, Maria Mohamed, Alaa Shahbaz, Amir Cureus Internal Medicine Atypical hemolytic uremic syndrome (aHUS), defines as non-Shiga toxin HUS, is thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and renal impairment. aHUS is associated with high morbidity and mortality, necessitating the need for an early diagnosis to limit target organ damage. Mutations or autoantibodies against specific complement factors over‐activate the complement system forming microthrombi. aHUS has the potential to cause multi‐organ system dysfunction, but it predominantly affects the kidneys. aHUS is treated with eculizumab, a terminal blocker of the complement system. Clostridium difficile infection is a rare precipitant of aHUS. We present a case of aHUS associated with Clostridium difficile infection in a 60-year-old female patient that was successfully treated with eculizumab. Cureus 2020-07-05 /pmc/articles/PMC7402547/ /pubmed/32775085 http://dx.doi.org/10.7759/cureus.9005 Text en Copyright © 2020, Khurshid et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Khurshid, Qasim
Mahmoud, Anas
Shahid, Maria
Mohamed, Alaa
Shahbaz, Amir
Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection
title Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection
title_full Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection
title_fullStr Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection
title_full_unstemmed Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection
title_short Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection
title_sort atypical hemolytic uremic syndrome associated with clostridium difficile infection
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402547/
https://www.ncbi.nlm.nih.gov/pubmed/32775085
http://dx.doi.org/10.7759/cureus.9005
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