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Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study

In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 µg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with na...

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Autores principales: Janapatla, Rajendra Prasad, Hsu, Mei-Hua, Chen, Chyi-Liang, Wei, Sung-Hsi, Yu, Ming-Jia, Su, Lin-Hui, Lin, Tzou-Yien, Chiu, Cheng-Hsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402562/
https://www.ncbi.nlm.nih.gov/pubmed/32444435
http://dx.doi.org/10.1136/thoraxjnl-2019-213878
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author Janapatla, Rajendra Prasad
Hsu, Mei-Hua
Chen, Chyi-Liang
Wei, Sung-Hsi
Yu, Ming-Jia
Su, Lin-Hui
Lin, Tzou-Yien
Chiu, Cheng-Hsun
author_facet Janapatla, Rajendra Prasad
Hsu, Mei-Hua
Chen, Chyi-Liang
Wei, Sung-Hsi
Yu, Ming-Jia
Su, Lin-Hui
Lin, Tzou-Yien
Chiu, Cheng-Hsun
author_sort Janapatla, Rajendra Prasad
collection PubMed
description In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 µg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific IgG could persist above 0.35 µg/mL longer (≥5 years) in the catch-up group than in the 2+1 and 3+1 immunisation groups. 14.5% of the carriage isolates belonged to PCV13 serotypes; statistical analysis revealed that a high serum IgG level (>10.96 µg/mL) will be required to eliminate the point-prevalence nasopharyngeal carriage of serotype 19A.
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spelling pubmed-74025622020-08-17 Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study Janapatla, Rajendra Prasad Hsu, Mei-Hua Chen, Chyi-Liang Wei, Sung-Hsi Yu, Ming-Jia Su, Lin-Hui Lin, Tzou-Yien Chiu, Cheng-Hsun Thorax Brief Communication In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 µg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific IgG could persist above 0.35 µg/mL longer (≥5 years) in the catch-up group than in the 2+1 and 3+1 immunisation groups. 14.5% of the carriage isolates belonged to PCV13 serotypes; statistical analysis revealed that a high serum IgG level (>10.96 µg/mL) will be required to eliminate the point-prevalence nasopharyngeal carriage of serotype 19A. BMJ Publishing Group 2020-08 2020-05-22 /pmc/articles/PMC7402562/ /pubmed/32444435 http://dx.doi.org/10.1136/thoraxjnl-2019-213878 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Janapatla, Rajendra Prasad
Hsu, Mei-Hua
Chen, Chyi-Liang
Wei, Sung-Hsi
Yu, Ming-Jia
Su, Lin-Hui
Lin, Tzou-Yien
Chiu, Cheng-Hsun
Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study
title Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study
title_full Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study
title_fullStr Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study
title_full_unstemmed Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study
title_short Persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study
title_sort persistence of immunity in children immunised with 13-valent pneumococcal conjugate vaccine and impact on nasopharyngeal carriage: a cross-sectional study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402562/
https://www.ncbi.nlm.nih.gov/pubmed/32444435
http://dx.doi.org/10.1136/thoraxjnl-2019-213878
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