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Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review
Papillary thyroid carcinoma is a slow-growing cancer with a generally good prognosis that sometimes have an aggressive behaviour. Metastases to neck lymph nodes is the first step of the diffusion. The central neck compartment is involved most commonly. The ipsilateral lateral neck compartments are u...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402576/ https://www.ncbi.nlm.nih.gov/pubmed/31074393 http://dx.doi.org/10.1186/s12893-018-0435-y |
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author | Attard, Andrea Paladino, Nunzia Cinzia Lo Monte, Attilio Ignazio Falco, Nicola Melfa, Giuseppina Rotolo, Giulia Rizzuto, Stefano Gulotta, Eliana Salamone, Giuseppe Bonventre, Sebastiano Scerrino, Gregorio Cocorullo, Gianfranco |
author_facet | Attard, Andrea Paladino, Nunzia Cinzia Lo Monte, Attilio Ignazio Falco, Nicola Melfa, Giuseppina Rotolo, Giulia Rizzuto, Stefano Gulotta, Eliana Salamone, Giuseppe Bonventre, Sebastiano Scerrino, Gregorio Cocorullo, Gianfranco |
author_sort | Attard, Andrea |
collection | PubMed |
description | Papillary thyroid carcinoma is a slow-growing cancer with a generally good prognosis that sometimes have an aggressive behaviour. Metastases to neck lymph nodes is the first step of the diffusion. The central neck compartment is involved most commonly. The ipsilateral lateral neck compartments are usually involved afterwards, and the involvement of the contralateral one is considered a quite rare occurrence. In more rare cases, metastases to lateral neck compartment without central lymph node metastasis (so called “skip metastases”) could be observed. Aim of this literature review study is to analyse the average incidence, pattern and risk factors of this occurrence. This study was performed according to PRISMA criteria. A final selection of 13 articles published in English language from 1997 to 2017 was performed. Any research article, review or meta-analysis was taken into consideration. Research was expanded considering the related references of articles. The incidence of skip metastases ranged from 1.6 to 21.8%. Risk factors such as age > 45 years, size < 5 mm and tumor located in the upper pole or isthmus of thyroid gland were found. Due to the frequency of skip metastases in thyroid cancer, a careful preoperative examination of lateral lymph nodes should be necessary. |
format | Online Article Text |
id | pubmed-7402576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74025762020-08-07 Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review Attard, Andrea Paladino, Nunzia Cinzia Lo Monte, Attilio Ignazio Falco, Nicola Melfa, Giuseppina Rotolo, Giulia Rizzuto, Stefano Gulotta, Eliana Salamone, Giuseppe Bonventre, Sebastiano Scerrino, Gregorio Cocorullo, Gianfranco BMC Surg Review Papillary thyroid carcinoma is a slow-growing cancer with a generally good prognosis that sometimes have an aggressive behaviour. Metastases to neck lymph nodes is the first step of the diffusion. The central neck compartment is involved most commonly. The ipsilateral lateral neck compartments are usually involved afterwards, and the involvement of the contralateral one is considered a quite rare occurrence. In more rare cases, metastases to lateral neck compartment without central lymph node metastasis (so called “skip metastases”) could be observed. Aim of this literature review study is to analyse the average incidence, pattern and risk factors of this occurrence. This study was performed according to PRISMA criteria. A final selection of 13 articles published in English language from 1997 to 2017 was performed. Any research article, review or meta-analysis was taken into consideration. Research was expanded considering the related references of articles. The incidence of skip metastases ranged from 1.6 to 21.8%. Risk factors such as age > 45 years, size < 5 mm and tumor located in the upper pole or isthmus of thyroid gland were found. Due to the frequency of skip metastases in thyroid cancer, a careful preoperative examination of lateral lymph nodes should be necessary. BioMed Central 2019-04-24 /pmc/articles/PMC7402576/ /pubmed/31074393 http://dx.doi.org/10.1186/s12893-018-0435-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Attard, Andrea Paladino, Nunzia Cinzia Lo Monte, Attilio Ignazio Falco, Nicola Melfa, Giuseppina Rotolo, Giulia Rizzuto, Stefano Gulotta, Eliana Salamone, Giuseppe Bonventre, Sebastiano Scerrino, Gregorio Cocorullo, Gianfranco Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review |
title | Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review |
title_full | Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review |
title_fullStr | Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review |
title_full_unstemmed | Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review |
title_short | Skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review |
title_sort | skip metastases to lateral cervical lymph nodes in differentiated thyroid cancer: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402576/ https://www.ncbi.nlm.nih.gov/pubmed/31074393 http://dx.doi.org/10.1186/s12893-018-0435-y |
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