Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. A major virulence factor of SARS-CoVs is the nonstructural protein 1 (Nsp1), which suppresses host gene expression by ribosome association. Here, we show t...

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Detalles Bibliográficos
Autores principales: Thoms, Matthias, Buschauer, Robert, Ameismeier, Michael, Koepke, Lennart, Denk, Timo, Hirschenberger, Maximilian, Kratzat, Hanna, Hayn, Manuel, Mackens-Kiani, Timur, Cheng, Jingdong, Straub, Jan H., Stürzel, Christina M., Fröhlich, Thomas, Berninghausen, Otto, Becker, Thomas, Kirchhoff, Frank, Sparrer, Konstantin M. J., Beckmann, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402621/
https://www.ncbi.nlm.nih.gov/pubmed/32680882
http://dx.doi.org/10.1126/science.abc8665

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