Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

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The COVID-19 pandemic has led to accelerated efforts to develop therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is metastable and difficult to produce recombinantly. Here, we characterized 100 structure-guided spike designs and identified 26 individual substi...

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Detalles Bibliográficos
Autores principales: Hsieh, Ching-Lin, Goldsmith, Jory A., Schaub, Jeffrey M., DiVenere, Andrea M., Kuo, Hung-Che, Javanmardi, Kamyab, Le, Kevin C., Wrapp, Daniel, Lee, Alison G., Liu, Yutong, Chou, Chia-Wei, Byrne, Patrick O., Hjorth, Christy K., Johnson, Nicole V., Ludes-Meyers, John, Nguyen, Annalee W., Park, Juyeon, Wang, Nianshuang, Amengor, Dzifa, Lavinder, Jason J., Ippolito, Gregory C., Maynard, Jennifer A., Finkelstein, Ilya J., McLellan, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
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Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402631/
https://www.ncbi.nlm.nih.gov/pubmed/32703906
http://dx.doi.org/10.1126/science.abd0826
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