A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling

R-spondin1 (Rspo1) has been featured as a Wnt agonist, serving as a potent niche factor for stem cells in many tissues. Here we unveil a novel role of Rspo1 in promoting estrogen receptor alpha (Esr1) expression, hence regulating the output of steroid hormone signaling in the mouse mammary gland. Th...

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Detalles Bibliográficos
Autores principales: Geng, Ajun, Wu, Ting, Cai, Cheguo, Song, Wenqian, Wang, Jiqiu, Yu, Qing Cissy, Zeng, Yi Arial
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402675/
https://www.ncbi.nlm.nih.gov/pubmed/32749219
http://dx.doi.org/10.7554/eLife.56434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402675/
https://www.ncbi.nlm.nih.gov/pubmed/32749219
http://dx.doi.org/10.7554/eLife.56434

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