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Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity
Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 to infectious virions. Using the multimammate...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402679/ https://www.ncbi.nlm.nih.gov/pubmed/32746966 http://dx.doi.org/10.7554/eLife.57626 |
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author | Fu, Yingying Cao, Rui Schäfer, Miriam Stephan, Sonja Braspenning-Wesch, Ilona Schmitt, Laura Bischoff, Ralf Müller, Martin Schäfer, Kai Vinzón, Sabrina E Rösl, Frank Hasche, Daniel |
author_facet | Fu, Yingying Cao, Rui Schäfer, Miriam Stephan, Sonja Braspenning-Wesch, Ilona Schmitt, Laura Bischoff, Ralf Müller, Martin Schäfer, Kai Vinzón, Sabrina E Rösl, Frank Hasche, Daniel |
author_sort | Fu, Yingying |
collection | PubMed |
description | Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 to infectious virions. Using the multimammate mouse Mastomys coucha as preclinical model, this is the first study demonstrating seroconversion against different L1 isoforms during the natural course of papillomavirus infection. Intriguingly, positivity with the cutaneous MnPV was accompanied by a strong seroresponse against a longer L1 isoform, but to our surprise, the raised antibodies were non-neutralizing. Only after a delay of around 4 months, protecting antibodies against the short L1 appeared, enabling the virus to successfully establish an infection. This argues for a novel humoral immune escape mechanism that may also have important implications on the interpretation of epidemiological data in terms of seropositivity and protection of PV infections in general. |
format | Online Article Text |
id | pubmed-7402679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-74026792020-08-06 Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity Fu, Yingying Cao, Rui Schäfer, Miriam Stephan, Sonja Braspenning-Wesch, Ilona Schmitt, Laura Bischoff, Ralf Müller, Martin Schäfer, Kai Vinzón, Sabrina E Rösl, Frank Hasche, Daniel eLife Microbiology and Infectious Disease Although many high-risk mucosal and cutaneous human papillomaviruses (HPVs) theoretically have the potential to synthesize L1 isoforms differing in length, previous seroepidemiological studies only focused on the short L1 variants, co-assembling with L2 to infectious virions. Using the multimammate mouse Mastomys coucha as preclinical model, this is the first study demonstrating seroconversion against different L1 isoforms during the natural course of papillomavirus infection. Intriguingly, positivity with the cutaneous MnPV was accompanied by a strong seroresponse against a longer L1 isoform, but to our surprise, the raised antibodies were non-neutralizing. Only after a delay of around 4 months, protecting antibodies against the short L1 appeared, enabling the virus to successfully establish an infection. This argues for a novel humoral immune escape mechanism that may also have important implications on the interpretation of epidemiological data in terms of seropositivity and protection of PV infections in general. eLife Sciences Publications, Ltd 2020-08-04 /pmc/articles/PMC7402679/ /pubmed/32746966 http://dx.doi.org/10.7554/eLife.57626 Text en © 2020, Fu et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Microbiology and Infectious Disease Fu, Yingying Cao, Rui Schäfer, Miriam Stephan, Sonja Braspenning-Wesch, Ilona Schmitt, Laura Bischoff, Ralf Müller, Martin Schäfer, Kai Vinzón, Sabrina E Rösl, Frank Hasche, Daniel Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity |
title | Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity |
title_full | Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity |
title_fullStr | Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity |
title_full_unstemmed | Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity |
title_short | Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity |
title_sort | expression of different l1 isoforms of mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity |
topic | Microbiology and Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402679/ https://www.ncbi.nlm.nih.gov/pubmed/32746966 http://dx.doi.org/10.7554/eLife.57626 |
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