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C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas

C-terminal binding protein-2 (CtBP2) a transcriptional corepressor, has been reported to involve in tumorigenesis and progression and predict a poor prognosis in several human cancers. However, few studies on CtBP2 in lung cancer tissues have been performed. In the present study, we first explored t...

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Autores principales: Li, Binfeng, Xiang, Zhengkai, Xiong, Fei, Yan, Baoguo, Huang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402787/
https://www.ncbi.nlm.nih.gov/pubmed/32756072
http://dx.doi.org/10.1097/MD.0000000000020076
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author Li, Binfeng
Xiang, Zhengkai
Xiong, Fei
Yan, Baoguo
Huang, Qi
author_facet Li, Binfeng
Xiang, Zhengkai
Xiong, Fei
Yan, Baoguo
Huang, Qi
author_sort Li, Binfeng
collection PubMed
description C-terminal binding protein-2 (CtBP2) a transcriptional corepressor, has been reported to involve in tumorigenesis and progression and predict a poor prognosis in several human cancers. However, few studies on CtBP2 in lung cancer tissues have been performed. In the present study, we first explored the CtBP2 gene expression profile from the the cancer genome atlas (TCGA) datasets, then western blot analysis and immunohistochemistry were performed to investigate and verified whether lung adenocarcinoma (LUAD) tissues exhibit deregulated CtBP2 expression. We evaluated the correlations between CtBP2 expression and the clinicopathological characteristics, and Kaplan–Meier survival analyses were performed to estimate the effect of CtBP2 expression on prognosis of LUAD patients. The results revealed that CtBP2 expression was significantly upregulated in LUAD tissues compared with normal lung tissues. Furthermore, increasing CtBP2 expression in LUAD was significantly associated with tumor differentiation (P = .028), tumor node metastasis (TNM) stage (P = .042). CtBP2 expression was significantly correlated with LUAD patients’ survival (P = .028). In conclusion, the present study revealed that CtBP2 protein is a novel prognostic marker for LUAD. A further large-scale study is needed to confirm the present results.
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spelling pubmed-74027872020-08-05 C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas Li, Binfeng Xiang, Zhengkai Xiong, Fei Yan, Baoguo Huang, Qi Medicine (Baltimore) 5700 C-terminal binding protein-2 (CtBP2) a transcriptional corepressor, has been reported to involve in tumorigenesis and progression and predict a poor prognosis in several human cancers. However, few studies on CtBP2 in lung cancer tissues have been performed. In the present study, we first explored the CtBP2 gene expression profile from the the cancer genome atlas (TCGA) datasets, then western blot analysis and immunohistochemistry were performed to investigate and verified whether lung adenocarcinoma (LUAD) tissues exhibit deregulated CtBP2 expression. We evaluated the correlations between CtBP2 expression and the clinicopathological characteristics, and Kaplan–Meier survival analyses were performed to estimate the effect of CtBP2 expression on prognosis of LUAD patients. The results revealed that CtBP2 expression was significantly upregulated in LUAD tissues compared with normal lung tissues. Furthermore, increasing CtBP2 expression in LUAD was significantly associated with tumor differentiation (P = .028), tumor node metastasis (TNM) stage (P = .042). CtBP2 expression was significantly correlated with LUAD patients’ survival (P = .028). In conclusion, the present study revealed that CtBP2 protein is a novel prognostic marker for LUAD. A further large-scale study is needed to confirm the present results. Wolters Kluwer Health 2020-07-31 /pmc/articles/PMC7402787/ /pubmed/32756072 http://dx.doi.org/10.1097/MD.0000000000020076 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Li, Binfeng
Xiang, Zhengkai
Xiong, Fei
Yan, Baoguo
Huang, Qi
C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas
title C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas
title_full C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas
title_fullStr C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas
title_full_unstemmed C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas
title_short C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas
title_sort c-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402787/
https://www.ncbi.nlm.nih.gov/pubmed/32756072
http://dx.doi.org/10.1097/MD.0000000000020076
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