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Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials

BACKGROUND: Bioresorbable vascular scaffolds (BVS) completely resorb within 3 years after placement into the coronary artery. The safety and effectiveness of bioabsorbable scaffolds are of critical importance during this 3-year period. OBJECTIVE: We performed a meta-analysis to compare the safety an...

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Autores principales: Ke, Junsong, Zhang, Hongyu, Huang, Jun, Lv, Ping, Chen, Yun, Xu, Kai, Yang, Wenxue, Tu, Bangyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402797/
https://www.ncbi.nlm.nih.gov/pubmed/32756213
http://dx.doi.org/10.1097/MD.0000000000021554
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author Ke, Junsong
Zhang, Hongyu
Huang, Jun
Lv, Ping
Chen, Yun
Xu, Kai
Yang, Wenxue
Tu, Bangyan
author_facet Ke, Junsong
Zhang, Hongyu
Huang, Jun
Lv, Ping
Chen, Yun
Xu, Kai
Yang, Wenxue
Tu, Bangyan
author_sort Ke, Junsong
collection PubMed
description BACKGROUND: Bioresorbable vascular scaffolds (BVS) completely resorb within 3 years after placement into the coronary artery. The safety and effectiveness of bioabsorbable scaffolds are of critical importance during this 3-year period. OBJECTIVE: We performed a meta-analysis to compare the safety and efficacy of BVS and second-generation drug-eluting stents (DES) at 3 years after implantation. METHODS: Published randomized trials comparing BVS to second-generation DES for the treatment of coronary artery disease were identified within PubMed, EMBASE, Cochrane Library, Web of Science, and relevant Web sites with publication dates through June 2019. The primary efficacy endpoint was target lesion failure. The primary safety endpoint was definite/probable stent/scaffold thrombosis. Secondary outcomes were cardiac death, target vessel myocardial infarction, ischemia-driven target lesion revascularization, and a patient-oriented composite end point. RESULTS: Six randomized controlled trials, with a total of 5,412 patients (BVS n = 3,177; DES n = 2,235), were included. At 3 years, BVS was associated with higher rates of target lesion failure (OR = 1.33, 95%CI: 1.10–1.60, P = 0.003) and definite/probable stent/scaffold thrombosis (OR = 3.75, 95% CI: 2.22–6.35, P < .00001)compared with DES. The incidence of target vessel myocardial infarction (OR = 1.68, 95% CI: 1.30–2.17, P < .0001), ischemia-driven target lesion revascularization (OR = 1.46, 95% CI: 1.14–1.86, P = .003), and the patient-oriented composite end point(OR = 1.20, 95% CI: 1.04–1.39, P = .01) were higher for those treated with BVS compared with DES. However, there was no significant difference in risk of cardiac death (OR = 0.94, 95%CI: 0.61–1.45, P = .79) between treatment groups. CONCLUSIONS: At the 3-year follow-up, BVS was inferior to second-generation DES in both safety and efficacy.
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spelling pubmed-74027972020-08-05 Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials Ke, Junsong Zhang, Hongyu Huang, Jun Lv, Ping Chen, Yun Xu, Kai Yang, Wenxue Tu, Bangyan Medicine (Baltimore) 3400 BACKGROUND: Bioresorbable vascular scaffolds (BVS) completely resorb within 3 years after placement into the coronary artery. The safety and effectiveness of bioabsorbable scaffolds are of critical importance during this 3-year period. OBJECTIVE: We performed a meta-analysis to compare the safety and efficacy of BVS and second-generation drug-eluting stents (DES) at 3 years after implantation. METHODS: Published randomized trials comparing BVS to second-generation DES for the treatment of coronary artery disease were identified within PubMed, EMBASE, Cochrane Library, Web of Science, and relevant Web sites with publication dates through June 2019. The primary efficacy endpoint was target lesion failure. The primary safety endpoint was definite/probable stent/scaffold thrombosis. Secondary outcomes were cardiac death, target vessel myocardial infarction, ischemia-driven target lesion revascularization, and a patient-oriented composite end point. RESULTS: Six randomized controlled trials, with a total of 5,412 patients (BVS n = 3,177; DES n = 2,235), were included. At 3 years, BVS was associated with higher rates of target lesion failure (OR = 1.33, 95%CI: 1.10–1.60, P = 0.003) and definite/probable stent/scaffold thrombosis (OR = 3.75, 95% CI: 2.22–6.35, P < .00001)compared with DES. The incidence of target vessel myocardial infarction (OR = 1.68, 95% CI: 1.30–2.17, P < .0001), ischemia-driven target lesion revascularization (OR = 1.46, 95% CI: 1.14–1.86, P = .003), and the patient-oriented composite end point(OR = 1.20, 95% CI: 1.04–1.39, P = .01) were higher for those treated with BVS compared with DES. However, there was no significant difference in risk of cardiac death (OR = 0.94, 95%CI: 0.61–1.45, P = .79) between treatment groups. CONCLUSIONS: At the 3-year follow-up, BVS was inferior to second-generation DES in both safety and efficacy. Wolters Kluwer Health 2020-07-31 /pmc/articles/PMC7402797/ /pubmed/32756213 http://dx.doi.org/10.1097/MD.0000000000021554 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3400
Ke, Junsong
Zhang, Hongyu
Huang, Jun
Lv, Ping
Chen, Yun
Xu, Kai
Yang, Wenxue
Tu, Bangyan
Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials
title Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials
title_full Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials
title_fullStr Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials
title_full_unstemmed Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials
title_short Three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: Meta-analysis of randomized trials
title_sort three-year outcomes of bioresorbable vascular scaffolds versus second-generation drug-eluting stents: meta-analysis of randomized trials
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402797/
https://www.ncbi.nlm.nih.gov/pubmed/32756213
http://dx.doi.org/10.1097/MD.0000000000021554
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