Occurrence of Immunoglobulin G4-related Disease during Chemotherapy for Advanced Breast Cancer

Immunoglobulin G4-related disease (IgG4-RD) is defined as an inflammatory lymphoproliferative disorder. The relationship between malignancies and IgG4-RD remains unclear. We herein present a case of IgG4-RD that occurred during chemotherapy for advanced breast cancer. In this case, it was challengin...

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Detalles Bibliográficos
Autores principales: Fujii, Yasutoshi, Doi, Mihoko, Yamane, Hiroaki, Morioka, Takehiko, Komichi, Daisuke, Nishisaka, Takashi, Shinozaki, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402958/
https://www.ncbi.nlm.nih.gov/pubmed/32269187
http://dx.doi.org/10.2169/internalmedicine.3386-19
Descripción
Sumario:Immunoglobulin G4-related disease (IgG4-RD) is defined as an inflammatory lymphoproliferative disorder. The relationship between malignancies and IgG4-RD remains unclear. We herein present a case of IgG4-RD that occurred during chemotherapy for advanced breast cancer. In this case, it was challenging to determine which of these diseases was responsible for the patient's mediastinal lymphadenopathy. Lymphadenopathy with IgG4-RD was diagnosed by assessing the reactivity to corticosteroids, which were used as premedication in chemotherapy, over time. The administration of prednisolone, which was initiated to treat active IgG4-RD, led to stable systemic therapy for malignancy. It is imperative to assess the disease activity and consider each treatment.

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