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The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial

STUDY DESIGN: A multi-centred, single-blinded randomised controlled trial. OBJECTIVES: To determine the effect of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury (SCI). SETTINGS: Seven hospitals in Australia and Asia. METHODS: One hun...

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Autores principales: Chen, Lydia W., Glinsky, Joanne V., Islam, Md. Shofiqul, Hossain, Muzaffor, Boswell-Ruys, Claire L., Kataria, Chitra, Redhead, Jason, Xiong, Yuan, Gollan, Emilie, Costa, Punam D., Denis, Sophie, Ben, Marsha, Chaudhary, Lovely, Wang, Jun, Hasnat, Md. Abu Khayer, Yeomans, Jayne, Gandevia, Simon C., Harvey, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402990/
https://www.ncbi.nlm.nih.gov/pubmed/32086442
http://dx.doi.org/10.1038/s41393-020-0439-1
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author Chen, Lydia W.
Glinsky, Joanne V.
Islam, Md. Shofiqul
Hossain, Muzaffor
Boswell-Ruys, Claire L.
Kataria, Chitra
Redhead, Jason
Xiong, Yuan
Gollan, Emilie
Costa, Punam D.
Denis, Sophie
Ben, Marsha
Chaudhary, Lovely
Wang, Jun
Hasnat, Md. Abu Khayer
Yeomans, Jayne
Gandevia, Simon C.
Harvey, Lisa A.
author_facet Chen, Lydia W.
Glinsky, Joanne V.
Islam, Md. Shofiqul
Hossain, Muzaffor
Boswell-Ruys, Claire L.
Kataria, Chitra
Redhead, Jason
Xiong, Yuan
Gollan, Emilie
Costa, Punam D.
Denis, Sophie
Ben, Marsha
Chaudhary, Lovely
Wang, Jun
Hasnat, Md. Abu Khayer
Yeomans, Jayne
Gandevia, Simon C.
Harvey, Lisa A.
author_sort Chen, Lydia W.
collection PubMed
description STUDY DESIGN: A multi-centred, single-blinded randomised controlled trial. OBJECTIVES: To determine the effect of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury (SCI). SETTINGS: Seven hospitals in Australia and Asia. METHODS: One hundred and twenty people with recent SCI undergoing inpatient rehabilitation were randomised to either a Treatment or Control Group. One major muscle group from an upper or lower limb was selected if the muscle had grade 1 or grade 2 strength on a standard six-point manual muscle test. Participants allocated to the Treatment Group performed 10,000 isolated contractions of the selected muscle group, as well as usual care in 48 sessions over 8 weeks. Participants allocated to the Control Group received usual care alone. Participants were assessed at baseline and 8 weeks by a blinded assessor. The primary outcome was voluntary muscle strength on a 13-point manual muscle test. There were three secondary outcomes capturing therapists’ and participants’ perceptions of strength and function. RESULTS: The mean between-group difference of voluntary strength at 8 weeks was 0.4/13 points (95% confidence interval −0.5 to 1.4) in favour of the Treatment Group. There were no notable between-group differences on any secondary outcome. CONCLUSION: Ten thousand isolated contractions of very weak muscles in people with SCI over 8 weeks has either no or a very small effect on voluntary strength.
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spelling pubmed-74029902020-08-17 The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial Chen, Lydia W. Glinsky, Joanne V. Islam, Md. Shofiqul Hossain, Muzaffor Boswell-Ruys, Claire L. Kataria, Chitra Redhead, Jason Xiong, Yuan Gollan, Emilie Costa, Punam D. Denis, Sophie Ben, Marsha Chaudhary, Lovely Wang, Jun Hasnat, Md. Abu Khayer Yeomans, Jayne Gandevia, Simon C. Harvey, Lisa A. Spinal Cord Article STUDY DESIGN: A multi-centred, single-blinded randomised controlled trial. OBJECTIVES: To determine the effect of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury (SCI). SETTINGS: Seven hospitals in Australia and Asia. METHODS: One hundred and twenty people with recent SCI undergoing inpatient rehabilitation were randomised to either a Treatment or Control Group. One major muscle group from an upper or lower limb was selected if the muscle had grade 1 or grade 2 strength on a standard six-point manual muscle test. Participants allocated to the Treatment Group performed 10,000 isolated contractions of the selected muscle group, as well as usual care in 48 sessions over 8 weeks. Participants allocated to the Control Group received usual care alone. Participants were assessed at baseline and 8 weeks by a blinded assessor. The primary outcome was voluntary muscle strength on a 13-point manual muscle test. There were three secondary outcomes capturing therapists’ and participants’ perceptions of strength and function. RESULTS: The mean between-group difference of voluntary strength at 8 weeks was 0.4/13 points (95% confidence interval −0.5 to 1.4) in favour of the Treatment Group. There were no notable between-group differences on any secondary outcome. CONCLUSION: Ten thousand isolated contractions of very weak muscles in people with SCI over 8 weeks has either no or a very small effect on voluntary strength. Nature Publishing Group UK 2020-02-21 2020 /pmc/articles/PMC7402990/ /pubmed/32086442 http://dx.doi.org/10.1038/s41393-020-0439-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Lydia W.
Glinsky, Joanne V.
Islam, Md. Shofiqul
Hossain, Muzaffor
Boswell-Ruys, Claire L.
Kataria, Chitra
Redhead, Jason
Xiong, Yuan
Gollan, Emilie
Costa, Punam D.
Denis, Sophie
Ben, Marsha
Chaudhary, Lovely
Wang, Jun
Hasnat, Md. Abu Khayer
Yeomans, Jayne
Gandevia, Simon C.
Harvey, Lisa A.
The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
title The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
title_full The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
title_fullStr The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
title_full_unstemmed The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
title_short The effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
title_sort effects of 10,000 voluntary contractions over 8 weeks on the strength of very weak muscles in people with spinal cord injury: a randomised controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402990/
https://www.ncbi.nlm.nih.gov/pubmed/32086442
http://dx.doi.org/10.1038/s41393-020-0439-1
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