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Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective

Coronavirus Disease 2019 (COVID-19) caused by a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first reported in Wuhan, China at the end of December 2019. SARS-CoV-2 is a highly pathogenic zoonotic virus and closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and...

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Autores principales: Khan, Suliman, Tombuloglu, Huseyin, Hassanein, Sameh E., Rehman, Suriya, Bozkurt, Ayhan, Cevik, Emre, Abdel-Ghany, Shaimaa, Nabi, Ghulam, Ali, Ashaq, Sabit, Hussein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403098/
https://www.ncbi.nlm.nih.gov/pubmed/32763302
http://dx.doi.org/10.1016/j.ejphar.2020.173447
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author Khan, Suliman
Tombuloglu, Huseyin
Hassanein, Sameh E.
Rehman, Suriya
Bozkurt, Ayhan
Cevik, Emre
Abdel-Ghany, Shaimaa
Nabi, Ghulam
Ali, Ashaq
Sabit, Hussein
author_facet Khan, Suliman
Tombuloglu, Huseyin
Hassanein, Sameh E.
Rehman, Suriya
Bozkurt, Ayhan
Cevik, Emre
Abdel-Ghany, Shaimaa
Nabi, Ghulam
Ali, Ashaq
Sabit, Hussein
author_sort Khan, Suliman
collection PubMed
description Coronavirus Disease 2019 (COVID-19) caused by a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first reported in Wuhan, China at the end of December 2019. SARS-CoV-2 is a highly pathogenic zoonotic virus and closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The COVID-19 was declared as a global pandemic due to its high infectiousness, and worldwide morbidities and mortalities. The Chinese scientists at the start of the outbreak reported genome sequences, which made the characterization of glycoproteins and other structural proteins possible. Moreover, researchers across the world have widely focused on understanding basic biology, developing vaccines, and therapeutic drugs against the COVID-19. However, until now, no promising treatment options, as well as vaccines, are available. In this review, we have described SARS-CoV-2's genome, transmission, and pathogenicity. We also discussed novel potential therapeutic agents that can help to treat the COVID-19 patients.
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spelling pubmed-74030982020-08-05 Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective Khan, Suliman Tombuloglu, Huseyin Hassanein, Sameh E. Rehman, Suriya Bozkurt, Ayhan Cevik, Emre Abdel-Ghany, Shaimaa Nabi, Ghulam Ali, Ashaq Sabit, Hussein Eur J Pharmacol Full Length Article Coronavirus Disease 2019 (COVID-19) caused by a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first reported in Wuhan, China at the end of December 2019. SARS-CoV-2 is a highly pathogenic zoonotic virus and closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The COVID-19 was declared as a global pandemic due to its high infectiousness, and worldwide morbidities and mortalities. The Chinese scientists at the start of the outbreak reported genome sequences, which made the characterization of glycoproteins and other structural proteins possible. Moreover, researchers across the world have widely focused on understanding basic biology, developing vaccines, and therapeutic drugs against the COVID-19. However, until now, no promising treatment options, as well as vaccines, are available. In this review, we have described SARS-CoV-2's genome, transmission, and pathogenicity. We also discussed novel potential therapeutic agents that can help to treat the COVID-19 patients. Elsevier B.V. 2020-11-05 2020-08-05 /pmc/articles/PMC7403098/ /pubmed/32763302 http://dx.doi.org/10.1016/j.ejphar.2020.173447 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Full Length Article
Khan, Suliman
Tombuloglu, Huseyin
Hassanein, Sameh E.
Rehman, Suriya
Bozkurt, Ayhan
Cevik, Emre
Abdel-Ghany, Shaimaa
Nabi, Ghulam
Ali, Ashaq
Sabit, Hussein
Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective
title Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective
title_full Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective
title_fullStr Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective
title_full_unstemmed Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective
title_short Coronavirus diseases 2019: Current biological situation and potential therapeutic perspective
title_sort coronavirus diseases 2019: current biological situation and potential therapeutic perspective
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403098/
https://www.ncbi.nlm.nih.gov/pubmed/32763302
http://dx.doi.org/10.1016/j.ejphar.2020.173447
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