A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations

Protein kinase Cβ (PKCβ) expressed in mammalian cells as two splice variants, PKCβI and PKCβII, functions in the B cell receptor (BCR) signaling pathway and contributes to B cell development. We investigated the relative role of PKCβII in B cells by generating transgenic mice where expression of the...

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Detalles Bibliográficos
Autores principales: Azar, Ali A., Michie, Alison M., Tarafdar, Anuradha, Malik, Natasha, Menon, Geetha K., Till, Kathleen J., Vlatković, Nikolina, Slupsky, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403146/
https://www.ncbi.nlm.nih.gov/pubmed/32753714
http://dx.doi.org/10.1038/s41598-020-70191-y

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