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CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum
BACKGROUND: Adaptive drug resistance is an unfavourable prognostic factor in cancer therapy. Pemetrexed-resistant lung cancer cells possess high-metastatic ability via ERK–ZEB1 pathway-activated epithelial–mesenchymal transition. GMI is a fungal immunomodulatory protein that suppresses the survival...
Autores principales: | Hsin, I-Lun, Chiu, Ling-Yen, Ou, Chu-Chyn, Wu, Wen-Jun, Sheu, Gwo-Tarng, Ko, Jiunn-Liang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403151/ https://www.ncbi.nlm.nih.gov/pubmed/32448867 http://dx.doi.org/10.1038/s41416-020-0885-8 |
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