Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection

Calcium signaling and the AMP-activated protein kinase (AMPK) signaling networks broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to m...

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Autores principales: Dunn, Diana M., Munger, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403205/
https://www.ncbi.nlm.nih.gov/pubmed/32850483
http://dx.doi.org/10.3389/fcimb.2020.00384
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author Dunn, Diana M.
Munger, Joshua
author_facet Dunn, Diana M.
Munger, Joshua
author_sort Dunn, Diana M.
collection PubMed
description Calcium signaling and the AMP-activated protein kinase (AMPK) signaling networks broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to modulating calcium signaling, and HCMV infection has been found to be reliant on calcium signaling and AMPK activation. Here, we focus on the cell biology of calcium and AMPK signaling and what is currently known about how HCMV modulates these pathways to support HCMV infection and potentially contribute to oncomodulation.
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spelling pubmed-74032052020-08-25 Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection Dunn, Diana M. Munger, Joshua Front Cell Infect Microbiol Cellular and Infection Microbiology Calcium signaling and the AMP-activated protein kinase (AMPK) signaling networks broadly regulate numerous aspects of cell biology. Human Cytomegalovirus (HCMV) infection has been found to actively manipulate the calcium-AMPK signaling axis to support infection. Many HCMV genes have been linked to modulating calcium signaling, and HCMV infection has been found to be reliant on calcium signaling and AMPK activation. Here, we focus on the cell biology of calcium and AMPK signaling and what is currently known about how HCMV modulates these pathways to support HCMV infection and potentially contribute to oncomodulation. Frontiers Media S.A. 2020-07-29 /pmc/articles/PMC7403205/ /pubmed/32850483 http://dx.doi.org/10.3389/fcimb.2020.00384 Text en Copyright © 2020 Dunn and Munger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Dunn, Diana M.
Munger, Joshua
Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
title Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
title_full Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
title_fullStr Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
title_full_unstemmed Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
title_short Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection
title_sort interplay between calcium and ampk signaling in human cytomegalovirus infection
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403205/
https://www.ncbi.nlm.nih.gov/pubmed/32850483
http://dx.doi.org/10.3389/fcimb.2020.00384
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