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The Resolution Approach to Cystic Fibrosis Inflammation
Despite the high expectations associated with the recent introduction of CFTR modulators, airway inflammation still remains a relevant clinical issue in cystic fibrosis (CF). The classical anti-inflammatory drugs have shown very limited efficacy, when not being harmful, raising the question of wheth...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403222/ https://www.ncbi.nlm.nih.gov/pubmed/32848748 http://dx.doi.org/10.3389/fphar.2020.01129 |
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author | Recchiuti, Antonio Patruno, Sara Plebani, Roberto Romano, Mario |
author_facet | Recchiuti, Antonio Patruno, Sara Plebani, Roberto Romano, Mario |
author_sort | Recchiuti, Antonio |
collection | PubMed |
description | Despite the high expectations associated with the recent introduction of CFTR modulators, airway inflammation still remains a relevant clinical issue in cystic fibrosis (CF). The classical anti-inflammatory drugs have shown very limited efficacy, when not being harmful, raising the question of whether alternative approaches should be undertaken. Thus, a better knowledge of the mechanisms underlying the aberrant inflammation observed in CF is pivotal to develop more efficacious pharmacology. In this respect, the observation that endogenous proresolving pathways are defective in CF and that proresolving mediators, physiologically generated during an acute inflammatory reaction, do not completely suppress inflammation, but promote resolution, tissue healing and microbial clearance, without compromising immune host defense mechanisms, opens interesting therapeutic scenarios for CF. In this mini-review, we present the current knowledge and perspectives of proresolving pharmacology in CF, focusing on the specialized proresolving lipid mediators and selected peptides. |
format | Online Article Text |
id | pubmed-7403222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74032222020-08-25 The Resolution Approach to Cystic Fibrosis Inflammation Recchiuti, Antonio Patruno, Sara Plebani, Roberto Romano, Mario Front Pharmacol Pharmacology Despite the high expectations associated with the recent introduction of CFTR modulators, airway inflammation still remains a relevant clinical issue in cystic fibrosis (CF). The classical anti-inflammatory drugs have shown very limited efficacy, when not being harmful, raising the question of whether alternative approaches should be undertaken. Thus, a better knowledge of the mechanisms underlying the aberrant inflammation observed in CF is pivotal to develop more efficacious pharmacology. In this respect, the observation that endogenous proresolving pathways are defective in CF and that proresolving mediators, physiologically generated during an acute inflammatory reaction, do not completely suppress inflammation, but promote resolution, tissue healing and microbial clearance, without compromising immune host defense mechanisms, opens interesting therapeutic scenarios for CF. In this mini-review, we present the current knowledge and perspectives of proresolving pharmacology in CF, focusing on the specialized proresolving lipid mediators and selected peptides. Frontiers Media S.A. 2020-07-29 /pmc/articles/PMC7403222/ /pubmed/32848748 http://dx.doi.org/10.3389/fphar.2020.01129 Text en Copyright © 2020 Recchiuti, Patruno, Plebani and Romano http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Recchiuti, Antonio Patruno, Sara Plebani, Roberto Romano, Mario The Resolution Approach to Cystic Fibrosis Inflammation |
title | The Resolution Approach to Cystic Fibrosis Inflammation |
title_full | The Resolution Approach to Cystic Fibrosis Inflammation |
title_fullStr | The Resolution Approach to Cystic Fibrosis Inflammation |
title_full_unstemmed | The Resolution Approach to Cystic Fibrosis Inflammation |
title_short | The Resolution Approach to Cystic Fibrosis Inflammation |
title_sort | resolution approach to cystic fibrosis inflammation |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403222/ https://www.ncbi.nlm.nih.gov/pubmed/32848748 http://dx.doi.org/10.3389/fphar.2020.01129 |
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