Adjuvant formulated virus-like particles expressing native-like forms of the Lassa virus envelope surface glycoprotein are immunogenic and induce antibodies with broadly neutralizing activity

Lassa mammarenavirus (LASV) is a rodent-borne arenavirus endemic to several West African countries. It is the causative agent of human Lassa fever, an acute viral hemorrhagic fever disease. To date, no therapeutics or vaccines against LASV have obtained regulatory approval. Polyclonal neutralizing a...

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Detalles Bibliográficos
Autores principales: Müller, Helena, Fehling, Sarah Katharina, Dorna, Jens, Urbanowicz, Richard A., Oestereich, Lisa, Krebs, Yvonne, Kolesnikova, Larissa, Schauflinger, Martin, Krähling, Verena, Magassouba, N’Faly, Fichet-Calvet, Elisabeth, Ball, Jonathan K., Kaufmann, Andreas, Bauer, Stefan, Becker, Stephan, von Messling, Veronika, Strecker, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403343/
https://www.ncbi.nlm.nih.gov/pubmed/32802410
http://dx.doi.org/10.1038/s41541-020-00219-x

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