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Myasthenia Gravis and Physical Exercise: A Novel Paradigm

The benefits of physical exercise for healthy individuals are well-established, particularly in relation to reducing the risks of chronic lifestyle related diseases. Furthermore, physical exercise has been seen to provide beneficial effects in many chronic diseases such as multiple sclerosis, rheuma...

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Autores principales: O'Connor, Laura, Westerberg, Elisabet, Punga, Anna Rostedt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403401/
https://www.ncbi.nlm.nih.gov/pubmed/32849178
http://dx.doi.org/10.3389/fneur.2020.00675
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author O'Connor, Laura
Westerberg, Elisabet
Punga, Anna Rostedt
author_facet O'Connor, Laura
Westerberg, Elisabet
Punga, Anna Rostedt
author_sort O'Connor, Laura
collection PubMed
description The benefits of physical exercise for healthy individuals are well-established, particularly in relation to reducing the risks of chronic lifestyle related diseases. Furthermore, physical exercise has been seen to provide beneficial effects in many chronic diseases such as multiple sclerosis, rheumatoid arthritis, and chronic obstructive pulmonary disease and is therefore recommended as part of the treatment regimen. Myasthenia Gravis (MG) is a chronic autoimmune disease that causes neuromuscular transmission failure resulting in abnormal fatigable skeletal muscle weakness. In spite of this fluctuating skeletal muscle weakness, it is reasonable to assume that MG patients, like healthy individuals, could benefit from some of the positive effects of physical exercise. Yet exercise-related research in the field of MG is sparse and does not provide any guidelines on how MG patients should perform physical training in order to obtain exercise's favorable effects without risking disease deterioration or more pronounced muscle fatigue. A handful of recent studies report that MG patients with mild disease activity can adhere safely to general exercise recommendations, including resistance training and aerobic training regimens, without subjective or objective disease deterioration. These findings indicate that MG patients can indeed improve their functional muscle status as a result of aerobic and high-resistance strength training. This knowledge is important in order to establish collective as well as personalized guidelines on physical exercise for MG patients. This review discusses the present knowledge on physical exercise in MG.
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spelling pubmed-74034012020-08-25 Myasthenia Gravis and Physical Exercise: A Novel Paradigm O'Connor, Laura Westerberg, Elisabet Punga, Anna Rostedt Front Neurol Neurology The benefits of physical exercise for healthy individuals are well-established, particularly in relation to reducing the risks of chronic lifestyle related diseases. Furthermore, physical exercise has been seen to provide beneficial effects in many chronic diseases such as multiple sclerosis, rheumatoid arthritis, and chronic obstructive pulmonary disease and is therefore recommended as part of the treatment regimen. Myasthenia Gravis (MG) is a chronic autoimmune disease that causes neuromuscular transmission failure resulting in abnormal fatigable skeletal muscle weakness. In spite of this fluctuating skeletal muscle weakness, it is reasonable to assume that MG patients, like healthy individuals, could benefit from some of the positive effects of physical exercise. Yet exercise-related research in the field of MG is sparse and does not provide any guidelines on how MG patients should perform physical training in order to obtain exercise's favorable effects without risking disease deterioration or more pronounced muscle fatigue. A handful of recent studies report that MG patients with mild disease activity can adhere safely to general exercise recommendations, including resistance training and aerobic training regimens, without subjective or objective disease deterioration. These findings indicate that MG patients can indeed improve their functional muscle status as a result of aerobic and high-resistance strength training. This knowledge is important in order to establish collective as well as personalized guidelines on physical exercise for MG patients. This review discusses the present knowledge on physical exercise in MG. Frontiers Media S.A. 2020-07-29 /pmc/articles/PMC7403401/ /pubmed/32849178 http://dx.doi.org/10.3389/fneur.2020.00675 Text en Copyright © 2020 O'Connor, Westerberg and Punga. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
O'Connor, Laura
Westerberg, Elisabet
Punga, Anna Rostedt
Myasthenia Gravis and Physical Exercise: A Novel Paradigm
title Myasthenia Gravis and Physical Exercise: A Novel Paradigm
title_full Myasthenia Gravis and Physical Exercise: A Novel Paradigm
title_fullStr Myasthenia Gravis and Physical Exercise: A Novel Paradigm
title_full_unstemmed Myasthenia Gravis and Physical Exercise: A Novel Paradigm
title_short Myasthenia Gravis and Physical Exercise: A Novel Paradigm
title_sort myasthenia gravis and physical exercise: a novel paradigm
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403401/
https://www.ncbi.nlm.nih.gov/pubmed/32849178
http://dx.doi.org/10.3389/fneur.2020.00675
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