Cargando…

The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix

Voltage-gated potassium channels (Kv) allow ion permeation upon changes of the membrane electrostatic potential (Vm). Each subunit of these tetrameric channels is composed of six transmembrane helices, of which the anti-parallel helix bundle S1-S4 constitutes the voltage-sensor domain (VSD) and S5-S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bignucolo, Olivier, Bernèche, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403406/ https://www.ncbi.nlm.nih.gov/pubmed/32850956 http://dx.doi.org/10.3389/fmolb.2020.00162

Ejemplares similares

Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology
por: Tao, Xiao, et al.
Publicado: (2019)

Structural Basis of Lipid-Driven Conformational Transitions in the KvAP Voltage Sensing Domain
por: Li, Qufei, et al.
Publicado: (2014)

Artificial Modulation of the Gating Behavior of a K(+) Channel in a KvAP-DNA Chimera
por: Wang, Andrew, et al.
Publicado: (2011)

S6 Peptide Derived from KvAP Channel Shows Cooperativity in Gating on Bilayer Lipid Membrane
por: Malik, Chetan, et al.
Publicado: (2013)

Regulating Shaker Kv channel clustering by hetero-oligomerization
por: Nsasra, Esraa, et al.
Publicado: (2023)

Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function
por: Bignucolo, Olivier, et al.
Publicado: (2020)

Commentary: Synthetic Ubiquinones Specifically Bind to Mitochondrial Voltage-Dependent Anion Channel 1 (VDAC1) in Saccharomyces cerevisiae Mitochondria
por: Gutiérrez-Aguilar, Manuel
Publicado: (2017)

A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism
por: Crnjar, Alessandro, et al.
Publicado: (2021)

Computational Investigation of Voltage-Gated Sodium Channel β3 Subunit Dynamics
por: Glass, William G., et al.
Publicado: (2020)

Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate
por: Zangerl-Plessl, Eva-Maria, et al.
Publicado: (2023)

Exploring the deactivation mechanism of human β (2) adrenergic receptor by accelerated molecular dynamic simulations
por: Chen, Jianzhong, et al.
Publicado: (2022)

Rational Design and Synthesis of 3-Morpholine Linked Aromatic-Imino-1H-Indoles as Novel Kv1.5 Channel Inhibitors Sharing Vasodilation Effects
por: Qin, Wei, et al.
Publicado: (2022)

Involvement of pore helix in voltage-dependent inactivation of TRPM5 channel
por: Uchida, Kunitoshi, et al.
Publicado: (2021)

On the Helix Propensity in Generalized Born Solvent Descriptions of Modeling the Dark Proteome
por: Olson, Mark A.
Publicado: (2017)

Differential Modulation of the Voltage-Gated Na(+) Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14
por: Singh, Aditya K., et al.
Publicado: (2021)

Protein and Organic-Molecular Crystallography With 300kV Electrons on a Direct Electron Detector
por: Takaba, Kiyofumi, et al.
Publicado: (2021)

Imaging Voltage with Microbial Rhodopsins
por: Zhang, Xiao Min, et al.
Publicado: (2021)

Corrigendum: Protein and Organic-Molecular Crystallography with 300kV Electrons on a Direct Electron Detector
por: Takaba, Kiyofumi, et al.
Publicado: (2021)

Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines
por: Khan, Abbas, et al.
Publicado: (2020)

Kv11 (ether‐à‐go‐go‐related gene) voltage‐dependent K(+) channels promote resonance and oscillation of subthreshold membrane potentials
por: Matsuoka, Toshinori, et al.
Publicado: (2020)

Cardiolipin occupancy profiles of YidC paralogs reveal the significance of respective TM2 helix residues in determining paralog-specific phenotypes
por: Mishra, Surabhi, et al.
Publicado: (2023)

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer
por: Comes, Núria, et al.
Publicado: (2013)

Re-evaluation of Diadenosine Tetraphosphate (Ap(4)A) From a Stress Metabolite to Bona Fide Secondary Messenger
por: Ferguson, Freya, et al.
Publicado: (2020)

Genome-Wide Enhancer Analysis Reveals the Role of AP-1 Transcription Factor in Head and Neck Squamous Cell Carcinoma
por: Wang, Chen-Yu, et al.
Publicado: (2021)

Is MYND Domain-Mediated Assembly of SMYD3 Complexes Involved in Calcium Dependent Signaling?
por: Zhang, Yingxue, et al.
Publicado: (2019)

Transcription factor Ap2b regulates the mouse autosomal recessive polycystic kidney disease genes, Pkhd1 and Cys1
por: Wu, Maoqing, et al.
Publicado: (2023)

Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix
por: Bril’kov, Maxim S., et al.
Publicado: (2022)

Deubiquitinase Inhibitor b-AP15 Attenuated LPS-Induced Inflammation via Inhibiting ERK1/2, JNK, and NF-Kappa B
por: Zhang, Fangcheng, et al.
Publicado: (2020)

Long Non-Coding RNA AP000695.2 Acts as a Novel Prognostic Biomarker and Regulates the Cell Growth and Migration of Lung Adenocarcinoma
por: Wang, Chunyan, et al.
Publicado: (2022)

The effect of allyl isothiocyanate on chondrocyte phenotype is matrix stiffness-dependent: Possible involvement of TRPA1 activation
por: Che, Hui, et al.
Publicado: (2023)

Phosphorylation regulates the sensitivity of voltage‐gated Kv7.2 channels towards phosphatidylinositol‐4,5‐bisphosphate
por: Salzer, Isabella, et al.
Publicado: (2016)

Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site
por: Roy, Sophie, et al.
Publicado: (2022)

Photoactivation of a Mechanosensitive Channel
por: Crea, Fucsia, et al.
Publicado: (2022)

LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis
por: Mei, Haijun, et al.
Publicado: (2021)

Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels
por: van der Horst, Jennifer, et al.
Publicado: (2020)

Kv1.3 is the exclusive voltage-gated K(+) channel of platelets and megakaryocytes: roles in membrane potential, Ca(2+) signalling and platelet count
por: McCloskey, Conor, et al.
Publicado: (2010)

Editorial: The Role of Calcium Channels in Human Health and Disease
por: Zhang, Peng, et al.
Publicado: (2022)

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir
por: Fagnen, Charline, et al.
Publicado: (2021)

Editorial: Recent advancements in modeling and simulations of ion channels
por: Furini, Simone, et al.
Publicado: (2022)

Unveiling the Gating Mechanism of CRAC Channel: A Computational Study
por: Guardiani, Carlo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7tf8ec0dqs00f8gjkloqkaile1