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The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation
A common missense variant in SLC39A8 is convincingly associated with schizophrenia and several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in undetectable serum manganese (Mn) and a Congenital Disorder of Glycosylation (CDG) due to the exquisite sensitivity of glyc...
Autores principales: | Mealer, Robert G., Jenkins, Bruce G., Chen, Chia-Yen, Daly, Mark J., Ge, Tian, Lehoux, Sylvain, Marquardt, Thorsten, Palmer, Christopher D., Park, Julien H., Parsons, Patrick J., Sackstein, Robert, Williams, Sarah E., Cummings, Richard D., Scolnick, Edward M., Smoller, Jordan W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403432/ https://www.ncbi.nlm.nih.gov/pubmed/32753748 http://dx.doi.org/10.1038/s41598-020-70108-9 |
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