Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing

Burn injury in the craniofacial region causes significant health and psychosocial consequences and presents unique reconstructive challenges. Healing of severely burned skin and underlying soft tissue is a dynamic process involving many pathophysiological factors, often leading to devastating outcom...

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Autores principales: Kwon, Sun Hyung, Barrera, Janos A., Noishiki, Chikage, Chen, Kellen, Henn, Dominic, Sheckter, Clifford C., Gurtner, Geoffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403506/
https://www.ncbi.nlm.nih.gov/pubmed/32848859
http://dx.doi.org/10.3389/fphys.2020.00916
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author Kwon, Sun Hyung
Barrera, Janos A.
Noishiki, Chikage
Chen, Kellen
Henn, Dominic
Sheckter, Clifford C.
Gurtner, Geoffrey C.
author_facet Kwon, Sun Hyung
Barrera, Janos A.
Noishiki, Chikage
Chen, Kellen
Henn, Dominic
Sheckter, Clifford C.
Gurtner, Geoffrey C.
author_sort Kwon, Sun Hyung
collection PubMed
description Burn injury in the craniofacial region causes significant health and psychosocial consequences and presents unique reconstructive challenges. Healing of severely burned skin and underlying soft tissue is a dynamic process involving many pathophysiological factors, often leading to devastating outcomes such as the formation of hypertrophic scars and debilitating contractures. There are limited treatment options currently used for post-burn scar mitigation but recent advances in our knowledge of the cellular and molecular wound and scar pathophysiology have allowed for development of new treatment concepts. Clinical effectiveness of these experimental therapies is currently being evaluated. In this review, we discuss current topical therapies for craniofacial burn injuries and emerging new therapeutic concepts that are highly translational.
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spelling pubmed-74035062020-08-25 Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing Kwon, Sun Hyung Barrera, Janos A. Noishiki, Chikage Chen, Kellen Henn, Dominic Sheckter, Clifford C. Gurtner, Geoffrey C. Front Physiol Physiology Burn injury in the craniofacial region causes significant health and psychosocial consequences and presents unique reconstructive challenges. Healing of severely burned skin and underlying soft tissue is a dynamic process involving many pathophysiological factors, often leading to devastating outcomes such as the formation of hypertrophic scars and debilitating contractures. There are limited treatment options currently used for post-burn scar mitigation but recent advances in our knowledge of the cellular and molecular wound and scar pathophysiology have allowed for development of new treatment concepts. Clinical effectiveness of these experimental therapies is currently being evaluated. In this review, we discuss current topical therapies for craniofacial burn injuries and emerging new therapeutic concepts that are highly translational. Frontiers Media S.A. 2020-07-29 /pmc/articles/PMC7403506/ /pubmed/32848859 http://dx.doi.org/10.3389/fphys.2020.00916 Text en Copyright © 2020 Kwon, Barrera, Noishiki, Chen, Henn, Sheckter and Gurtner. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Kwon, Sun Hyung
Barrera, Janos A.
Noishiki, Chikage
Chen, Kellen
Henn, Dominic
Sheckter, Clifford C.
Gurtner, Geoffrey C.
Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing
title Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing
title_full Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing
title_fullStr Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing
title_full_unstemmed Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing
title_short Current and Emerging Topical Scar Mitigation Therapies for Craniofacial Burn Wound Healing
title_sort current and emerging topical scar mitigation therapies for craniofacial burn wound healing
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403506/
https://www.ncbi.nlm.nih.gov/pubmed/32848859
http://dx.doi.org/10.3389/fphys.2020.00916
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