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Drug Delivery System in the Treatment of Diabetes Mellitus

Diabetes mellitus has been described as a chronic endocrine and metabolic disease, which is characterized by hyperglycemia and the coexistence of multiple complications. At present, the drugs widely applied in clinical treatment of diabetes mellitus mainly include insulin, insulin analogs, non-insul...

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Autores principales: Zhao, Ruichen, Lu, Zhiguo, Yang, Jun, Zhang, Liqun, Li, Yan, Zhang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403527/
https://www.ncbi.nlm.nih.gov/pubmed/32850735
http://dx.doi.org/10.3389/fbioe.2020.00880
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author Zhao, Ruichen
Lu, Zhiguo
Yang, Jun
Zhang, Liqun
Li, Yan
Zhang, Xin
author_facet Zhao, Ruichen
Lu, Zhiguo
Yang, Jun
Zhang, Liqun
Li, Yan
Zhang, Xin
author_sort Zhao, Ruichen
collection PubMed
description Diabetes mellitus has been described as a chronic endocrine and metabolic disease, which is characterized by hyperglycemia and the coexistence of multiple complications. At present, the drugs widely applied in clinical treatment of diabetes mellitus mainly include insulin, insulin analogs, non-insulin oral hypoglycemic drugs and genetic drugs. Nevertheless, there is still no complete therapy strategy for diabetes mellitus management by far due to the intrinsic deficiencies of drugs and limits in administration routes such as the adverse reactions caused by long-term subcutaneous injection and various challenges in oral administration, such as enzymatic degradation, chemical instability and poor gastrointestinal absorption. Therefore, it is remarkably necessary to develop appropriate delivery systems and explore complete therapy strategies according to the characters of drugs and diabetes mellitus. Delivery systems have been found to be potentially beneficial in many aspects for effective diabetes treatment, such as improving the stability of drugs, overcoming different biological barriers in vivo to increase bioavailability, and acting as an intelligent automatized system to mimic endogenous insulin delivery and reduce the risk of hypoglycemia. This review aims to provide an overview related with the research advances, development trend of drug therapy and the application of delivery systems in the treatment diabetes mellitus, which could offer reference for the application of various drugs in the field of diabetes mellitus treatment.
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spelling pubmed-74035272020-08-25 Drug Delivery System in the Treatment of Diabetes Mellitus Zhao, Ruichen Lu, Zhiguo Yang, Jun Zhang, Liqun Li, Yan Zhang, Xin Front Bioeng Biotechnol Bioengineering and Biotechnology Diabetes mellitus has been described as a chronic endocrine and metabolic disease, which is characterized by hyperglycemia and the coexistence of multiple complications. At present, the drugs widely applied in clinical treatment of diabetes mellitus mainly include insulin, insulin analogs, non-insulin oral hypoglycemic drugs and genetic drugs. Nevertheless, there is still no complete therapy strategy for diabetes mellitus management by far due to the intrinsic deficiencies of drugs and limits in administration routes such as the adverse reactions caused by long-term subcutaneous injection and various challenges in oral administration, such as enzymatic degradation, chemical instability and poor gastrointestinal absorption. Therefore, it is remarkably necessary to develop appropriate delivery systems and explore complete therapy strategies according to the characters of drugs and diabetes mellitus. Delivery systems have been found to be potentially beneficial in many aspects for effective diabetes treatment, such as improving the stability of drugs, overcoming different biological barriers in vivo to increase bioavailability, and acting as an intelligent automatized system to mimic endogenous insulin delivery and reduce the risk of hypoglycemia. This review aims to provide an overview related with the research advances, development trend of drug therapy and the application of delivery systems in the treatment diabetes mellitus, which could offer reference for the application of various drugs in the field of diabetes mellitus treatment. Frontiers Media S.A. 2020-07-29 /pmc/articles/PMC7403527/ /pubmed/32850735 http://dx.doi.org/10.3389/fbioe.2020.00880 Text en Copyright © 2020 Zhao, Lu, Yang, Zhang, Li and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Zhao, Ruichen
Lu, Zhiguo
Yang, Jun
Zhang, Liqun
Li, Yan
Zhang, Xin
Drug Delivery System in the Treatment of Diabetes Mellitus
title Drug Delivery System in the Treatment of Diabetes Mellitus
title_full Drug Delivery System in the Treatment of Diabetes Mellitus
title_fullStr Drug Delivery System in the Treatment of Diabetes Mellitus
title_full_unstemmed Drug Delivery System in the Treatment of Diabetes Mellitus
title_short Drug Delivery System in the Treatment of Diabetes Mellitus
title_sort drug delivery system in the treatment of diabetes mellitus
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403527/
https://www.ncbi.nlm.nih.gov/pubmed/32850735
http://dx.doi.org/10.3389/fbioe.2020.00880
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