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Assessing the Impact of Losmapimod on Proteinuria in Idiopathic Focal Segmental Glomerulosclerosis

INTRODUCTION: Idiopathic focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease. In preclinical models and biopsies of human FSGS kidneys, p38 mitogen-activated protein kinase (MAPK) has demonstrated enhanced activity; and p38 MAPK inhibition h...

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Detalles Bibliográficos
Autores principales:	Gipson, Debbie S., Hladunewich, Michelle A., Lafayette, Richard, Sedor, John R., Rovin, Brad H., Barbour, Sean J., McMahon, Alan, Jennette, J. Charles, Nachman, Patrick H., Willette, Robert N., Paglione, Marcella, Gao, Feng, Ross Terres, Jorge Alfonso, Vallow, Sue, Holland, M. Claire, Thorneloe, Kevin S., Sprecher, Dennis L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403548/ https://www.ncbi.nlm.nih.gov/pubmed/32775822 http://dx.doi.org/10.1016/j.ekir.2020.05.024

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