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Biological Efficacy and Safety of Niacinamide in Patients With ADPKD

INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst enlargement, leading to kidney failure. Sirtuin-1 is upregulated in ADPKD and accelerates disease progression by deacetylating p53. Niacinamide is a dietary supplement that inhibits sirtuins at hi...

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Detalles Bibliográficos
Autores principales:	El Ters, Mireille, Zhou, Xia, Lepping, Rebecca J., Lu, Pengcheng, Karcher, Rainer T., Mahnken, Jonathan D., Brooks, William M., Winklhofer, Franz T., Li, Xiaogang, Yu, Alan S.L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403550/ https://www.ncbi.nlm.nih.gov/pubmed/32775826 http://dx.doi.org/10.1016/j.ekir.2020.06.002

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