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Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients

Many hypotheses have been postulated to define the etiology of sporadic Parkinson’s and Alzheimer’s disorders (PD and AD) but there is no consensus on what causes these devastating age-related diseases. Braak staging of both pathologies helped researchers to better understand the progression and to...

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Autores principales: Esteves, A. R., Cardoso, S. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403590/
https://www.ncbi.nlm.nih.gov/pubmed/32753661
http://dx.doi.org/10.1038/s41598-020-70174-z
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author Esteves, A. R.
Cardoso, S. M.
author_facet Esteves, A. R.
Cardoso, S. M.
author_sort Esteves, A. R.
collection PubMed
description Many hypotheses have been postulated to define the etiology of sporadic Parkinson’s and Alzheimer’s disorders (PD and AD) but there is no consensus on what causes these devastating age-related diseases. Braak staging of both pathologies helped researchers to better understand the progression and to identify their prodromal and symptomatic phases. Indeed, it is well accepted that Lewy body pathology and neurofibrillary tangles appearance correlates with disease progression and severity of symptoms in PD and AD, respectively. Additionally, several studies in PD and AD models try to disclose which cellular mechanisms are defaulted and trigger the neurodegenerative process that culminates with neuronal death causing PD and AD classical symptomatology. Herein, we determined expression levels of proteins involved in microtubule assembly, autophagic-lysosomal pathway and unfolded protein response in the cortex, hippocampus and SNpc of PD and AD patients, vascular dementia patients and aged-match controls. The differential expression allowed us to determine which pathways are determinant to synaptic dysfunction and to establish a time line for disease progression. Our results allow us to challenge the hypothesis that both PD and AD pathologies are caused by α-synuclein or Aβ pathology propagation throughout the brain in a prion-like manner.
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spelling pubmed-74035902020-08-07 Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients Esteves, A. R. Cardoso, S. M. Sci Rep Article Many hypotheses have been postulated to define the etiology of sporadic Parkinson’s and Alzheimer’s disorders (PD and AD) but there is no consensus on what causes these devastating age-related diseases. Braak staging of both pathologies helped researchers to better understand the progression and to identify their prodromal and symptomatic phases. Indeed, it is well accepted that Lewy body pathology and neurofibrillary tangles appearance correlates with disease progression and severity of symptoms in PD and AD, respectively. Additionally, several studies in PD and AD models try to disclose which cellular mechanisms are defaulted and trigger the neurodegenerative process that culminates with neuronal death causing PD and AD classical symptomatology. Herein, we determined expression levels of proteins involved in microtubule assembly, autophagic-lysosomal pathway and unfolded protein response in the cortex, hippocampus and SNpc of PD and AD patients, vascular dementia patients and aged-match controls. The differential expression allowed us to determine which pathways are determinant to synaptic dysfunction and to establish a time line for disease progression. Our results allow us to challenge the hypothesis that both PD and AD pathologies are caused by α-synuclein or Aβ pathology propagation throughout the brain in a prion-like manner. Nature Publishing Group UK 2020-08-04 /pmc/articles/PMC7403590/ /pubmed/32753661 http://dx.doi.org/10.1038/s41598-020-70174-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Esteves, A. R.
Cardoso, S. M.
Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
title Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
title_full Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
title_fullStr Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
title_full_unstemmed Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
title_short Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
title_sort differential protein expression in diverse brain areas of parkinson’s and alzheimer’s disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403590/
https://www.ncbi.nlm.nih.gov/pubmed/32753661
http://dx.doi.org/10.1038/s41598-020-70174-z
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