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Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells

Toxoplasmic encephalitis is an AIDS-defining condition. The decline of IFN-γ-producing CD4(+) T cells in AIDS is a major contributing factor in reactivation of quiescent Toxoplasma gondii to an actively replicating stage of infection. Hence, it is important to characterize CD4-independent mechanisms...

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Detalles Bibliográficos
Autores principales:	Kupz, Andreas, Pai, Saparna, Giacomin, Paul R., Whan, Jennifer A., Walker, Robert A., Hammoudi, Pierre-Mehdi, Smith, Nicholas C., Miller, Catherine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403597/ https://www.ncbi.nlm.nih.gov/pubmed/32753607 http://dx.doi.org/10.1038/s41598-020-70102-1

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