Synonymous Site-to-Site Substitution Rate Variation Dramatically Inflates False Positive Rates of Selection Analyses: Ignore at Your Own Peril

Most molecular evolutionary studies of natural selection maintain the decades-old assumption that synonymous substitution rate variation (SRV) across sites within genes occurs at levels that are either nonexistent or negligible. However, numerous studies challenge this assumption from a biological p...

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Detalles Bibliográficos
Autores principales: Wisotsky, Sadie R, Kosakovsky Pond, Sergei L, Shank, Stephen D, Muse, Spencer V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403620/
https://www.ncbi.nlm.nih.gov/pubmed/32068869
http://dx.doi.org/10.1093/molbev/msaa037

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