Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications

We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroc...

Descripción completa

Detalles Bibliográficos
Autores principales: Caini, Saverio, Bellerba, Federica, Corso, Federica, Díaz-Basabe, Angélica, Natoli, Gioacchino, Paget, John, Facciotti, Federica, De Angelis, Simone Pietro, Raimondi, Sara, Palli, Domenico, Mazzarella, Luca, Pelicci, Pier Giuseppe, Vineis, Paolo, Gandini, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403641/
https://www.ncbi.nlm.nih.gov/pubmed/32553061
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.23.2000980
_version_ 1783566982436618240
author Caini, Saverio
Bellerba, Federica
Corso, Federica
Díaz-Basabe, Angélica
Natoli, Gioacchino
Paget, John
Facciotti, Federica
De Angelis, Simone Pietro
Raimondi, Sara
Palli, Domenico
Mazzarella, Luca
Pelicci, Pier Giuseppe
Vineis, Paolo
Gandini, Sara
author_facet Caini, Saverio
Bellerba, Federica
Corso, Federica
Díaz-Basabe, Angélica
Natoli, Gioacchino
Paget, John
Facciotti, Federica
De Angelis, Simone Pietro
Raimondi, Sara
Palli, Domenico
Mazzarella, Luca
Pelicci, Pier Giuseppe
Vineis, Paolo
Gandini, Sara
author_sort Caini, Saverio
collection PubMed
description We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
format Online
Article
Text
id pubmed-7403641
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher European Centre for Disease Prevention and Control (ECDC)
record_format MEDLINE/PubMed
spelling pubmed-74036412020-08-17 Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications Caini, Saverio Bellerba, Federica Corso, Federica Díaz-Basabe, Angélica Natoli, Gioacchino Paget, John Facciotti, Federica De Angelis, Simone Pietro Raimondi, Sara Palli, Domenico Mazzarella, Luca Pelicci, Pier Giuseppe Vineis, Paolo Gandini, Sara Euro Surveill Rapid Communication We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas. European Centre for Disease Prevention and Control (ECDC) 2020-06-11 /pmc/articles/PMC7403641/ /pubmed/32553061 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.23.2000980 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Caini, Saverio
Bellerba, Federica
Corso, Federica
Díaz-Basabe, Angélica
Natoli, Gioacchino
Paget, John
Facciotti, Federica
De Angelis, Simone Pietro
Raimondi, Sara
Palli, Domenico
Mazzarella, Luca
Pelicci, Pier Giuseppe
Vineis, Paolo
Gandini, Sara
Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
title Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
title_full Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
title_fullStr Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
title_full_unstemmed Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
title_short Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
title_sort meta-analysis of diagnostic performance of serological tests for sars-cov-2 antibodies up to 25 april 2020 and public health implications
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403641/
https://www.ncbi.nlm.nih.gov/pubmed/32553061
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.23.2000980
work_keys_str_mv AT cainisaverio metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT bellerbafederica metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT corsofederica metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT diazbasabeangelica metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT natoligioacchino metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT pagetjohn metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT facciottifederica metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT deangelissimonepietro metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT raimondisara metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT pallidomenico metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT mazzarellaluca metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT peliccipiergiuseppe metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT vineispaolo metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications
AT gandinisara metaanalysisofdiagnosticperformanceofserologicaltestsforsarscov2antibodiesupto25april2020andpublichealthimplications

Ejemplares similares