Intellectual disability‐associated gene ftsj1 is responsible for 2′‐O‐methylation of specific tRNAs

tRNA modifications at the anti‐codon loop are critical for accurate decoding. FTSJ1 was hypothesized to be a human tRNA 2′‐O‐methyltransferase. tRNA(Phe)(GAA) from intellectual disability patients with mutations in ftsj1 lacks 2′‐O‐methylation at C32 and G34 (Cm32 and Gm34). However, the catalytic a...

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Detalles Bibliográficos
Autores principales: Li, Jing, Wang, Yan‐Nan, Xu, Bei‐Si, Liu, Ya‐Ping, Zhou, Mi, Long, Tao, Li, Hao, Dong, Han, Nie, Yan, Chen, Peng R, Wang, En‐Duo, Liu, Ru‐Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403668/
https://www.ncbi.nlm.nih.gov/pubmed/32558197
http://dx.doi.org/10.15252/embr.202050095

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