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Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study

BACKGROUND: Children with esophageal atresia (EA) have risk of gastroesophageal reflux disease (GERD), suggesting reflux monitoring for prompt management. AIM: To evaluate GERD in children with EA and specific symptom association from combined Video with Multichannel Intraluminal Impedance and pH (M...

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Autores principales: Maholarnkij, Settachote, Sanpavat, Anapat, Decharun, Katawaetee, Dumrisilp, Termpong, Tubjareon, Chomchanat, Kanghom, Benjawan, Patcharatrakul, Tanisa, Chaijitraruch, Nataruks, Chongsrisawat, Voranush, Sintusek, Palittiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403792/
https://www.ncbi.nlm.nih.gov/pubmed/32821077
http://dx.doi.org/10.3748/wjg.v26.i28.4159
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author Maholarnkij, Settachote
Sanpavat, Anapat
Decharun, Katawaetee
Dumrisilp, Termpong
Tubjareon, Chomchanat
Kanghom, Benjawan
Patcharatrakul, Tanisa
Chaijitraruch, Nataruks
Chongsrisawat, Voranush
Sintusek, Palittiya
author_facet Maholarnkij, Settachote
Sanpavat, Anapat
Decharun, Katawaetee
Dumrisilp, Termpong
Tubjareon, Chomchanat
Kanghom, Benjawan
Patcharatrakul, Tanisa
Chaijitraruch, Nataruks
Chongsrisawat, Voranush
Sintusek, Palittiya
author_sort Maholarnkij, Settachote
collection PubMed
description BACKGROUND: Children with esophageal atresia (EA) have risk of gastroesophageal reflux disease (GERD), suggesting reflux monitoring for prompt management. AIM: To evaluate GERD in children with EA and specific symptom association from combined Video with Multichannel Intraluminal Impedance and pH (MII-pH) study. METHODS: Children diagnosed with EA with suspected GERD and followed up at King Chulalongkorn Memorial Hospital between January 2000 and December 2018 were prospectively studied. All underwent esophagogastroduodenoscopy with esophageal biopsy and Video MII-pH study on the same day. Symptoms of GERD which included both esophageal and extra-esophageal symptom were recorded from video monitoring and abnormal reflux from MII-pH study based on the statement from the European Paediatric Impedance Group. Prevalence of GERD was also reported by using histopathology as a gold standard. Endoscopic appearance was recorded using Los Angeles Classification and esophagitis severity was graded using Esohisto criteria. RESULTS: Fifteen children were recruited with age of 3.1 (2.2, 9.8) years (40%, male) and the common type was C (93.3%). The symptoms recorded were cough (75.2%), vomiting (15.2%), irritability or unexplained crying (7.6%) and dysphagia (1.9%) with the symptom-reflux association of 45.7%, 89%, 71% and 0%, respectively. There were abnormal endoscopic appearance in 52.9%, esophagitis in 64.7% and high reflux score in 47.1%. Video MII-pH study has high diagnostic value with the sensitivity, specificity and accuracy of 72.7%, 100% and 82.4%, respectively. CONCLUSION: Prevalence of GERD in children with EA was high. Video MII-pH study to detect GERD in children with EA had high diagnostic value with the trend of specific symptom association.
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spelling pubmed-74037922020-08-19 Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study Maholarnkij, Settachote Sanpavat, Anapat Decharun, Katawaetee Dumrisilp, Termpong Tubjareon, Chomchanat Kanghom, Benjawan Patcharatrakul, Tanisa Chaijitraruch, Nataruks Chongsrisawat, Voranush Sintusek, Palittiya World J Gastroenterol Observational Study BACKGROUND: Children with esophageal atresia (EA) have risk of gastroesophageal reflux disease (GERD), suggesting reflux monitoring for prompt management. AIM: To evaluate GERD in children with EA and specific symptom association from combined Video with Multichannel Intraluminal Impedance and pH (MII-pH) study. METHODS: Children diagnosed with EA with suspected GERD and followed up at King Chulalongkorn Memorial Hospital between January 2000 and December 2018 were prospectively studied. All underwent esophagogastroduodenoscopy with esophageal biopsy and Video MII-pH study on the same day. Symptoms of GERD which included both esophageal and extra-esophageal symptom were recorded from video monitoring and abnormal reflux from MII-pH study based on the statement from the European Paediatric Impedance Group. Prevalence of GERD was also reported by using histopathology as a gold standard. Endoscopic appearance was recorded using Los Angeles Classification and esophagitis severity was graded using Esohisto criteria. RESULTS: Fifteen children were recruited with age of 3.1 (2.2, 9.8) years (40%, male) and the common type was C (93.3%). The symptoms recorded were cough (75.2%), vomiting (15.2%), irritability or unexplained crying (7.6%) and dysphagia (1.9%) with the symptom-reflux association of 45.7%, 89%, 71% and 0%, respectively. There were abnormal endoscopic appearance in 52.9%, esophagitis in 64.7% and high reflux score in 47.1%. Video MII-pH study has high diagnostic value with the sensitivity, specificity and accuracy of 72.7%, 100% and 82.4%, respectively. CONCLUSION: Prevalence of GERD in children with EA was high. Video MII-pH study to detect GERD in children with EA had high diagnostic value with the trend of specific symptom association. Baishideng Publishing Group Inc 2020-07-28 2020-07-28 /pmc/articles/PMC7403792/ /pubmed/32821077 http://dx.doi.org/10.3748/wjg.v26.i28.4159 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Observational Study
Maholarnkij, Settachote
Sanpavat, Anapat
Decharun, Katawaetee
Dumrisilp, Termpong
Tubjareon, Chomchanat
Kanghom, Benjawan
Patcharatrakul, Tanisa
Chaijitraruch, Nataruks
Chongsrisawat, Voranush
Sintusek, Palittiya
Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study
title Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study
title_full Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study
title_fullStr Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study
title_full_unstemmed Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study
title_short Detection of reflux-symptom association in children with esophageal atresia by video-pH-impedance study
title_sort detection of reflux-symptom association in children with esophageal atresia by video-ph-impedance study
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403792/
https://www.ncbi.nlm.nih.gov/pubmed/32821077
http://dx.doi.org/10.3748/wjg.v26.i28.4159
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