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Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis

Background: Ae. aegypti mosquitoes stably transfected with the intracellular bacterium Wolbachia pipientis ( wMel strain) have been deployed for biocontrol of dengue and related arboviral diseases in multiple countries. Field releases in northern Australia have previously demonstrated near eliminati...

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Autores principales: Indriani, Citra, Tantowijoyo, Warsito, Rancès, Edwige, Andari, Bekti, Prabowo, Equatori, Yusdi, Dedik, Ansari, Muhammad Ridwan, Wardana, Dwi Satria, Supriyati, Endah, Nurhayati, Indah, Ernesia, Inggrid, Setyawan, Sigit, Fitriana, Iva, Arguni, Eggi, Amelia, Yudiria, Ahmad, Riris Andono, Jewell, Nicholas P., Dufault, Suzanne M., Ryan, Peter A., Green, Benjamin R., McAdam, Thomas F., O'Neill, Scott L., Tanamas, Stephanie K., Simmons, Cameron P., Anders, Katherine L., Utarini, Adi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403856/
https://www.ncbi.nlm.nih.gov/pubmed/32803130
http://dx.doi.org/10.12688/gatesopenres.13122.1
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author Indriani, Citra
Tantowijoyo, Warsito
Rancès, Edwige
Andari, Bekti
Prabowo, Equatori
Yusdi, Dedik
Ansari, Muhammad Ridwan
Wardana, Dwi Satria
Supriyati, Endah
Nurhayati, Indah
Ernesia, Inggrid
Setyawan, Sigit
Fitriana, Iva
Arguni, Eggi
Amelia, Yudiria
Ahmad, Riris Andono
Jewell, Nicholas P.
Dufault, Suzanne M.
Ryan, Peter A.
Green, Benjamin R.
McAdam, Thomas F.
O'Neill, Scott L.
Tanamas, Stephanie K.
Simmons, Cameron P.
Anders, Katherine L.
Utarini, Adi
author_facet Indriani, Citra
Tantowijoyo, Warsito
Rancès, Edwige
Andari, Bekti
Prabowo, Equatori
Yusdi, Dedik
Ansari, Muhammad Ridwan
Wardana, Dwi Satria
Supriyati, Endah
Nurhayati, Indah
Ernesia, Inggrid
Setyawan, Sigit
Fitriana, Iva
Arguni, Eggi
Amelia, Yudiria
Ahmad, Riris Andono
Jewell, Nicholas P.
Dufault, Suzanne M.
Ryan, Peter A.
Green, Benjamin R.
McAdam, Thomas F.
O'Neill, Scott L.
Tanamas, Stephanie K.
Simmons, Cameron P.
Anders, Katherine L.
Utarini, Adi
author_sort Indriani, Citra
collection PubMed
description Background: Ae. aegypti mosquitoes stably transfected with the intracellular bacterium Wolbachia pipientis ( wMel strain) have been deployed for biocontrol of dengue and related arboviral diseases in multiple countries. Field releases in northern Australia have previously demonstrated near elimination of local dengue transmission from Wolbachia-treated communities, and pilot studies in Indonesia have demonstrated the feasibility and acceptability of the method. We conducted a quasi-experimental trial to evaluate the impact of scaled Wolbachia releases on dengue incidence in an endemic setting in Indonesia. Methods: In Yogyakarta City, Indonesia, following extensive community engagement, wMel Wolbachia-carrying mosquitoes were released every two weeks for 13–15 rounds over seven months in 2016–17, in a contiguous 5 km (2) area (population 65,000). A 3 km (2) area (population 34,000) on the opposite side of the city was selected a priori as an untreated control area. Passive surveillance data on notified hospitalised dengue patients was used to evaluate the epidemiological impact of Wolbachia deployments, using controlled interrupted time-series analysis. Results: Rapid and sustained introgression of wMel Wolbachia into local Ae. aegypti populations was achieved. Thirty-four dengue cases were notified from the intervention area and 53 from the control area (incidence 26 vs 79 per 100,000 person-years) during 24 months following Wolbachia deployment. This corresponded in the regression model to a 73% reduction in dengue incidence (95% confidence interval 49%,86%) associated with the Wolbachia intervention. Exploratory analysis including 6 months additional post-intervention observations showed a small strengthening of this effect (30 vs 115 per 100,000 person-years; 76% reduction in incidence, 95%CI 60%,86%). Conclusions: We demonstrate a significant reduction in dengue incidence following successful introgression of Wolbachia into local Ae. aegypti populations in an endemic setting in Indonesia. These findings are consistent with previous field trials in northern Australia, and support the effectiveness of this novel approach for dengue control.
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spelling pubmed-74038562020-08-13 Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis Indriani, Citra Tantowijoyo, Warsito Rancès, Edwige Andari, Bekti Prabowo, Equatori Yusdi, Dedik Ansari, Muhammad Ridwan Wardana, Dwi Satria Supriyati, Endah Nurhayati, Indah Ernesia, Inggrid Setyawan, Sigit Fitriana, Iva Arguni, Eggi Amelia, Yudiria Ahmad, Riris Andono Jewell, Nicholas P. Dufault, Suzanne M. Ryan, Peter A. Green, Benjamin R. McAdam, Thomas F. O'Neill, Scott L. Tanamas, Stephanie K. Simmons, Cameron P. Anders, Katherine L. Utarini, Adi Gates Open Res Research Article Background: Ae. aegypti mosquitoes stably transfected with the intracellular bacterium Wolbachia pipientis ( wMel strain) have been deployed for biocontrol of dengue and related arboviral diseases in multiple countries. Field releases in northern Australia have previously demonstrated near elimination of local dengue transmission from Wolbachia-treated communities, and pilot studies in Indonesia have demonstrated the feasibility and acceptability of the method. We conducted a quasi-experimental trial to evaluate the impact of scaled Wolbachia releases on dengue incidence in an endemic setting in Indonesia. Methods: In Yogyakarta City, Indonesia, following extensive community engagement, wMel Wolbachia-carrying mosquitoes were released every two weeks for 13–15 rounds over seven months in 2016–17, in a contiguous 5 km (2) area (population 65,000). A 3 km (2) area (population 34,000) on the opposite side of the city was selected a priori as an untreated control area. Passive surveillance data on notified hospitalised dengue patients was used to evaluate the epidemiological impact of Wolbachia deployments, using controlled interrupted time-series analysis. Results: Rapid and sustained introgression of wMel Wolbachia into local Ae. aegypti populations was achieved. Thirty-four dengue cases were notified from the intervention area and 53 from the control area (incidence 26 vs 79 per 100,000 person-years) during 24 months following Wolbachia deployment. This corresponded in the regression model to a 73% reduction in dengue incidence (95% confidence interval 49%,86%) associated with the Wolbachia intervention. Exploratory analysis including 6 months additional post-intervention observations showed a small strengthening of this effect (30 vs 115 per 100,000 person-years; 76% reduction in incidence, 95%CI 60%,86%). Conclusions: We demonstrate a significant reduction in dengue incidence following successful introgression of Wolbachia into local Ae. aegypti populations in an endemic setting in Indonesia. These findings are consistent with previous field trials in northern Australia, and support the effectiveness of this novel approach for dengue control. F1000 Research Limited 2020-05-11 /pmc/articles/PMC7403856/ /pubmed/32803130 http://dx.doi.org/10.12688/gatesopenres.13122.1 Text en Copyright: © 2020 Indriani C et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Indriani, Citra
Tantowijoyo, Warsito
Rancès, Edwige
Andari, Bekti
Prabowo, Equatori
Yusdi, Dedik
Ansari, Muhammad Ridwan
Wardana, Dwi Satria
Supriyati, Endah
Nurhayati, Indah
Ernesia, Inggrid
Setyawan, Sigit
Fitriana, Iva
Arguni, Eggi
Amelia, Yudiria
Ahmad, Riris Andono
Jewell, Nicholas P.
Dufault, Suzanne M.
Ryan, Peter A.
Green, Benjamin R.
McAdam, Thomas F.
O'Neill, Scott L.
Tanamas, Stephanie K.
Simmons, Cameron P.
Anders, Katherine L.
Utarini, Adi
Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis
title Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis
title_full Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis
title_fullStr Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis
title_full_unstemmed Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis
title_short Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis
title_sort reduced dengue incidence following deployments of wolbachia-infected aedes aegypti in yogyakarta, indonesia: a quasi-experimental trial using controlled interrupted time series analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403856/
https://www.ncbi.nlm.nih.gov/pubmed/32803130
http://dx.doi.org/10.12688/gatesopenres.13122.1
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