Cargando…
Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review
OBJECTIVE: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria. ST...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mosby
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403869/ https://www.ncbi.nlm.nih.gov/pubmed/32768466 http://dx.doi.org/10.1016/j.jpeds.2020.08.003 |
_version_ | 1783567026543919104 |
---|---|
author | Abrams, Joseph Y. Godfred-Cato, Shana E. Oster, Matthew E. Chow, Eric J. Koumans, Emilia H. Bryant, Bobbi Leung, Jessica W. Belay, Ermias D. |
author_facet | Abrams, Joseph Y. Godfred-Cato, Shana E. Oster, Matthew E. Chow, Eric J. Koumans, Emilia H. Bryant, Bobbi Leung, Jessica W. Belay, Ermias D. |
author_sort | Abrams, Joseph Y. |
collection | PubMed |
description | OBJECTIVE: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria. STUDY DESIGN: MIS-C studies were identified by searching PubMed and Embase as well as preprint repositories and article references to identify studies of MIS-C cases published from April 25, 2020, through June 29, 2020. MIS-C study metadata were assessed and information on case demographics, clinical symptoms, laboratory measurements, treatments, and outcomes were summarized and contrasted between studies. RESULTS: Eight studies were identified representing a total of 440 MIS-C cases. Inclusion criteria varied by study: 3 studies selected patients diagnosed with Kawasaki disease, 2 required cardiovascular involvement, and 3 had broader multisystem inclusion criteria. Median age of patients by study ranged from 7.3 to 10 years, and 59% of patients were male. Across all studies, the proportion of patients with positive results for severe acute respiratory syndrome coronavirus 2 reverse transcriptase-polymerase chain reaction tests ranged from 13% to 69% and for serology, from 75% to 100%. Patients with MIS-C had high prevalence of gastrointestinal (87%), dermatologic/mucocutaneous (73%), and cardiovascular (71%) symptoms. Prevalence of cardiovascular, neurologic, and respiratory system involvement significantly differed by study inclusion criteria. All studies reported elevated C-reactive protein, interleukin-6, and fibrinogen levels for at least 75% of patients in each study. CONCLUSIONS: This systematic review of MIS-C studies assists with understanding this newly identified syndrome and may be useful in developing a refined, universal case definition of MIS-C. |
format | Online Article Text |
id | pubmed-7403869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Mosby |
record_format | MEDLINE/PubMed |
spelling | pubmed-74038692020-08-05 Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review Abrams, Joseph Y. Godfred-Cato, Shana E. Oster, Matthew E. Chow, Eric J. Koumans, Emilia H. Bryant, Bobbi Leung, Jessica W. Belay, Ermias D. J Pediatr Original Article OBJECTIVE: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria. STUDY DESIGN: MIS-C studies were identified by searching PubMed and Embase as well as preprint repositories and article references to identify studies of MIS-C cases published from April 25, 2020, through June 29, 2020. MIS-C study metadata were assessed and information on case demographics, clinical symptoms, laboratory measurements, treatments, and outcomes were summarized and contrasted between studies. RESULTS: Eight studies were identified representing a total of 440 MIS-C cases. Inclusion criteria varied by study: 3 studies selected patients diagnosed with Kawasaki disease, 2 required cardiovascular involvement, and 3 had broader multisystem inclusion criteria. Median age of patients by study ranged from 7.3 to 10 years, and 59% of patients were male. Across all studies, the proportion of patients with positive results for severe acute respiratory syndrome coronavirus 2 reverse transcriptase-polymerase chain reaction tests ranged from 13% to 69% and for serology, from 75% to 100%. Patients with MIS-C had high prevalence of gastrointestinal (87%), dermatologic/mucocutaneous (73%), and cardiovascular (71%) symptoms. Prevalence of cardiovascular, neurologic, and respiratory system involvement significantly differed by study inclusion criteria. All studies reported elevated C-reactive protein, interleukin-6, and fibrinogen levels for at least 75% of patients in each study. CONCLUSIONS: This systematic review of MIS-C studies assists with understanding this newly identified syndrome and may be useful in developing a refined, universal case definition of MIS-C. Mosby 2020-11 2020-08-05 /pmc/articles/PMC7403869/ /pubmed/32768466 http://dx.doi.org/10.1016/j.jpeds.2020.08.003 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Abrams, Joseph Y. Godfred-Cato, Shana E. Oster, Matthew E. Chow, Eric J. Koumans, Emilia H. Bryant, Bobbi Leung, Jessica W. Belay, Ermias D. Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review |
title | Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review |
title_full | Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review |
title_fullStr | Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review |
title_full_unstemmed | Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review |
title_short | Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review |
title_sort | multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403869/ https://www.ncbi.nlm.nih.gov/pubmed/32768466 http://dx.doi.org/10.1016/j.jpeds.2020.08.003 |
work_keys_str_mv | AT abramsjosephy multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview AT godfredcatoshanae multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview AT ostermatthewe multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview AT chowericj multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview AT koumansemiliah multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview AT bryantbobbi multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview AT leungjessicaw multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview AT belayermiasd multisysteminflammatorysyndromeinchildrenassociatedwithsevereacuterespiratorysyndromecoronavirus2asystematicreview |