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Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
Preeclampsia (PE) is a disorder that affects 3–5% of normal pregnancies. It was believed for a long time that the kidney, similarly to all vessels in the whole system, only sustained endothelial damage. The current knowledge gives rise to a presumption that the main role in the development of protei...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403979/ https://www.ncbi.nlm.nih.gov/pubmed/32708979 http://dx.doi.org/10.3390/ijms21145051 |
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author | Kwiatkowska, Ewa Stefańska, Katarzyna Zieliński, Maciej Sakowska, Justyna Jankowiak, Martyna Trzonkowski, Piotr Marek-Trzonkowska, Natalia Kwiatkowski, Sebastian |
author_facet | Kwiatkowska, Ewa Stefańska, Katarzyna Zieliński, Maciej Sakowska, Justyna Jankowiak, Martyna Trzonkowski, Piotr Marek-Trzonkowska, Natalia Kwiatkowski, Sebastian |
author_sort | Kwiatkowska, Ewa |
collection | PubMed |
description | Preeclampsia (PE) is a disorder that affects 3–5% of normal pregnancies. It was believed for a long time that the kidney, similarly to all vessels in the whole system, only sustained endothelial damage. The current knowledge gives rise to a presumption that the main role in the development of proteinuria is played by damage to the podocytes and their slit diaphragm. The podocyte damage mechanism in preeclampsia is connected to free VEGF and nitric oxide (NO) deficiency, and an increased concentration of endothelin-1 and oxidative stress. From national cohort studies, we know that women who had preeclampsia in at least one pregnancy carried five times the risk of developing end-stage renal disease (ESRD) when compared to women with physiological pregnancies. The focal segmental glomerulosclerosis (FSGS) is the dominant histopathological lesion in women with a history of PE. The kidney’s podocytes are not subject to replacement or proliferation. Podocyte depletion exceeding 20% resulted in FSGS, which is a reason for the later development of ESRD. In this review, we present the mechanism of kidney (especially podocytes) injury in preeclampsia. We try to explain how this damage affects further changes in the morphology and function of the kidneys after pregnancy. |
format | Online Article Text |
id | pubmed-7403979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74039792020-08-11 Podocytes—The Most Vulnerable Renal Cells in Preeclampsia Kwiatkowska, Ewa Stefańska, Katarzyna Zieliński, Maciej Sakowska, Justyna Jankowiak, Martyna Trzonkowski, Piotr Marek-Trzonkowska, Natalia Kwiatkowski, Sebastian Int J Mol Sci Review Preeclampsia (PE) is a disorder that affects 3–5% of normal pregnancies. It was believed for a long time that the kidney, similarly to all vessels in the whole system, only sustained endothelial damage. The current knowledge gives rise to a presumption that the main role in the development of proteinuria is played by damage to the podocytes and their slit diaphragm. The podocyte damage mechanism in preeclampsia is connected to free VEGF and nitric oxide (NO) deficiency, and an increased concentration of endothelin-1 and oxidative stress. From national cohort studies, we know that women who had preeclampsia in at least one pregnancy carried five times the risk of developing end-stage renal disease (ESRD) when compared to women with physiological pregnancies. The focal segmental glomerulosclerosis (FSGS) is the dominant histopathological lesion in women with a history of PE. The kidney’s podocytes are not subject to replacement or proliferation. Podocyte depletion exceeding 20% resulted in FSGS, which is a reason for the later development of ESRD. In this review, we present the mechanism of kidney (especially podocytes) injury in preeclampsia. We try to explain how this damage affects further changes in the morphology and function of the kidneys after pregnancy. MDPI 2020-07-17 /pmc/articles/PMC7403979/ /pubmed/32708979 http://dx.doi.org/10.3390/ijms21145051 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kwiatkowska, Ewa Stefańska, Katarzyna Zieliński, Maciej Sakowska, Justyna Jankowiak, Martyna Trzonkowski, Piotr Marek-Trzonkowska, Natalia Kwiatkowski, Sebastian Podocytes—The Most Vulnerable Renal Cells in Preeclampsia |
title | Podocytes—The Most Vulnerable Renal Cells in Preeclampsia |
title_full | Podocytes—The Most Vulnerable Renal Cells in Preeclampsia |
title_fullStr | Podocytes—The Most Vulnerable Renal Cells in Preeclampsia |
title_full_unstemmed | Podocytes—The Most Vulnerable Renal Cells in Preeclampsia |
title_short | Podocytes—The Most Vulnerable Renal Cells in Preeclampsia |
title_sort | podocytes—the most vulnerable renal cells in preeclampsia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403979/ https://www.ncbi.nlm.nih.gov/pubmed/32708979 http://dx.doi.org/10.3390/ijms21145051 |
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