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Podocytes—The Most Vulnerable Renal Cells in Preeclampsia

Preeclampsia (PE) is a disorder that affects 3–5% of normal pregnancies. It was believed for a long time that the kidney, similarly to all vessels in the whole system, only sustained endothelial damage. The current knowledge gives rise to a presumption that the main role in the development of protei...

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Autores principales: Kwiatkowska, Ewa, Stefańska, Katarzyna, Zieliński, Maciej, Sakowska, Justyna, Jankowiak, Martyna, Trzonkowski, Piotr, Marek-Trzonkowska, Natalia, Kwiatkowski, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403979/
https://www.ncbi.nlm.nih.gov/pubmed/32708979
http://dx.doi.org/10.3390/ijms21145051
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author Kwiatkowska, Ewa
Stefańska, Katarzyna
Zieliński, Maciej
Sakowska, Justyna
Jankowiak, Martyna
Trzonkowski, Piotr
Marek-Trzonkowska, Natalia
Kwiatkowski, Sebastian
author_facet Kwiatkowska, Ewa
Stefańska, Katarzyna
Zieliński, Maciej
Sakowska, Justyna
Jankowiak, Martyna
Trzonkowski, Piotr
Marek-Trzonkowska, Natalia
Kwiatkowski, Sebastian
author_sort Kwiatkowska, Ewa
collection PubMed
description Preeclampsia (PE) is a disorder that affects 3–5% of normal pregnancies. It was believed for a long time that the kidney, similarly to all vessels in the whole system, only sustained endothelial damage. The current knowledge gives rise to a presumption that the main role in the development of proteinuria is played by damage to the podocytes and their slit diaphragm. The podocyte damage mechanism in preeclampsia is connected to free VEGF and nitric oxide (NO) deficiency, and an increased concentration of endothelin-1 and oxidative stress. From national cohort studies, we know that women who had preeclampsia in at least one pregnancy carried five times the risk of developing end-stage renal disease (ESRD) when compared to women with physiological pregnancies. The focal segmental glomerulosclerosis (FSGS) is the dominant histopathological lesion in women with a history of PE. The kidney’s podocytes are not subject to replacement or proliferation. Podocyte depletion exceeding 20% resulted in FSGS, which is a reason for the later development of ESRD. In this review, we present the mechanism of kidney (especially podocytes) injury in preeclampsia. We try to explain how this damage affects further changes in the morphology and function of the kidneys after pregnancy.
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spelling pubmed-74039792020-08-11 Podocytes—The Most Vulnerable Renal Cells in Preeclampsia Kwiatkowska, Ewa Stefańska, Katarzyna Zieliński, Maciej Sakowska, Justyna Jankowiak, Martyna Trzonkowski, Piotr Marek-Trzonkowska, Natalia Kwiatkowski, Sebastian Int J Mol Sci Review Preeclampsia (PE) is a disorder that affects 3–5% of normal pregnancies. It was believed for a long time that the kidney, similarly to all vessels in the whole system, only sustained endothelial damage. The current knowledge gives rise to a presumption that the main role in the development of proteinuria is played by damage to the podocytes and their slit diaphragm. The podocyte damage mechanism in preeclampsia is connected to free VEGF and nitric oxide (NO) deficiency, and an increased concentration of endothelin-1 and oxidative stress. From national cohort studies, we know that women who had preeclampsia in at least one pregnancy carried five times the risk of developing end-stage renal disease (ESRD) when compared to women with physiological pregnancies. The focal segmental glomerulosclerosis (FSGS) is the dominant histopathological lesion in women with a history of PE. The kidney’s podocytes are not subject to replacement or proliferation. Podocyte depletion exceeding 20% resulted in FSGS, which is a reason for the later development of ESRD. In this review, we present the mechanism of kidney (especially podocytes) injury in preeclampsia. We try to explain how this damage affects further changes in the morphology and function of the kidneys after pregnancy. MDPI 2020-07-17 /pmc/articles/PMC7403979/ /pubmed/32708979 http://dx.doi.org/10.3390/ijms21145051 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kwiatkowska, Ewa
Stefańska, Katarzyna
Zieliński, Maciej
Sakowska, Justyna
Jankowiak, Martyna
Trzonkowski, Piotr
Marek-Trzonkowska, Natalia
Kwiatkowski, Sebastian
Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
title Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
title_full Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
title_fullStr Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
title_full_unstemmed Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
title_short Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
title_sort podocytes—the most vulnerable renal cells in preeclampsia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403979/
https://www.ncbi.nlm.nih.gov/pubmed/32708979
http://dx.doi.org/10.3390/ijms21145051
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