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Role of RNA Oxidation in Neurodegenerative Diseases

In the history of nucleic acid research, DNA has always been the main research focus. After the sketch of the human genome was completed in 2000, RNA has been started to gain more attention due to its abundancies in the cell and its essential role in cellular physiology and pathologies. Recent studi...

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Autores principales: Liu, Ziqian, Chen, Xiatian, Li, Zhe, Ye, Wei, Ding, Hongyan, Li, Peifeng, Aung, Lynn Htet Htet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403986/
https://www.ncbi.nlm.nih.gov/pubmed/32708667
http://dx.doi.org/10.3390/ijms21145022
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author Liu, Ziqian
Chen, Xiatian
Li, Zhe
Ye, Wei
Ding, Hongyan
Li, Peifeng
Aung, Lynn Htet Htet
author_facet Liu, Ziqian
Chen, Xiatian
Li, Zhe
Ye, Wei
Ding, Hongyan
Li, Peifeng
Aung, Lynn Htet Htet
author_sort Liu, Ziqian
collection PubMed
description In the history of nucleic acid research, DNA has always been the main research focus. After the sketch of the human genome was completed in 2000, RNA has been started to gain more attention due to its abundancies in the cell and its essential role in cellular physiology and pathologies. Recent studies have shown that RNAs are susceptible to oxidative damage and oxidized RNA is able to break the RNA strand, and affect the protein synthesis, which can lead to cell degradation and cell death. Studies have shown that RNA oxidation is one of the early events in the formation and development of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. However, its molecular mechanism, as well as its impact on these diseases, are still unclear. In this article, we review the different types of RNA oxidative damage and the neurodegenerative diseases that are reported to be associated with RNA oxidative damage. In addition, we discuss recent findings on the association between RNA oxidative damage and the development of neurodegenerative diseases, which will have great significance for the development of novel strategies for the prevention and treatment of these diseases.
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spelling pubmed-74039862020-08-11 Role of RNA Oxidation in Neurodegenerative Diseases Liu, Ziqian Chen, Xiatian Li, Zhe Ye, Wei Ding, Hongyan Li, Peifeng Aung, Lynn Htet Htet Int J Mol Sci Review In the history of nucleic acid research, DNA has always been the main research focus. After the sketch of the human genome was completed in 2000, RNA has been started to gain more attention due to its abundancies in the cell and its essential role in cellular physiology and pathologies. Recent studies have shown that RNAs are susceptible to oxidative damage and oxidized RNA is able to break the RNA strand, and affect the protein synthesis, which can lead to cell degradation and cell death. Studies have shown that RNA oxidation is one of the early events in the formation and development of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. However, its molecular mechanism, as well as its impact on these diseases, are still unclear. In this article, we review the different types of RNA oxidative damage and the neurodegenerative diseases that are reported to be associated with RNA oxidative damage. In addition, we discuss recent findings on the association between RNA oxidative damage and the development of neurodegenerative diseases, which will have great significance for the development of novel strategies for the prevention and treatment of these diseases. MDPI 2020-07-16 /pmc/articles/PMC7403986/ /pubmed/32708667 http://dx.doi.org/10.3390/ijms21145022 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Ziqian
Chen, Xiatian
Li, Zhe
Ye, Wei
Ding, Hongyan
Li, Peifeng
Aung, Lynn Htet Htet
Role of RNA Oxidation in Neurodegenerative Diseases
title Role of RNA Oxidation in Neurodegenerative Diseases
title_full Role of RNA Oxidation in Neurodegenerative Diseases
title_fullStr Role of RNA Oxidation in Neurodegenerative Diseases
title_full_unstemmed Role of RNA Oxidation in Neurodegenerative Diseases
title_short Role of RNA Oxidation in Neurodegenerative Diseases
title_sort role of rna oxidation in neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403986/
https://www.ncbi.nlm.nih.gov/pubmed/32708667
http://dx.doi.org/10.3390/ijms21145022
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