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Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity
The curiosity and attention that researchers have devoted to alkaloids are due to their bioactivities, structural diversity, and intriguing chemistry. Marine-derived macrocyclic alkaloids (MDMAs) are considered to be a potential source of drugs. Trabectedin, a tetrahydroisoquinoline derivative, has...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404069/ https://www.ncbi.nlm.nih.gov/pubmed/32709048 http://dx.doi.org/10.3390/md18070368 |
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author | Althagbi, Hanan I. Alarif, Walied M. Al-Footy, Khalid O. Abdel-Lateff, Ahmed |
author_facet | Althagbi, Hanan I. Alarif, Walied M. Al-Footy, Khalid O. Abdel-Lateff, Ahmed |
author_sort | Althagbi, Hanan I. |
collection | PubMed |
description | The curiosity and attention that researchers have devoted to alkaloids are due to their bioactivities, structural diversity, and intriguing chemistry. Marine-derived macrocyclic alkaloids (MDMAs) are considered to be a potential source of drugs. Trabectedin, a tetrahydroisoquinoline derivative, has been approved for the treatment of metastatic soft tissue sarcoma and ovarian cancers. MDMAs displayed potent activities that enabled them to be used as anticancer, anti-invasion, antimalarial, antiplasmodial, and antimicrobial. This review presents the reported chemical structures, biological activities, and structure–activity relationships of macrocyclic alkaloids from marine organisms that have been published since their discovery until May 2020. This includes 204 compounds that are categorized under eight subclasses: pyrroles, quinolines, bis-quinolizidines, bis-1-oxaquinolizidines, 3-alkylpiperidines, manzamines, 3-alkyl pyridinium salts, and motuporamines. |
format | Online Article Text |
id | pubmed-7404069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74040692020-08-11 Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity Althagbi, Hanan I. Alarif, Walied M. Al-Footy, Khalid O. Abdel-Lateff, Ahmed Mar Drugs Review The curiosity and attention that researchers have devoted to alkaloids are due to their bioactivities, structural diversity, and intriguing chemistry. Marine-derived macrocyclic alkaloids (MDMAs) are considered to be a potential source of drugs. Trabectedin, a tetrahydroisoquinoline derivative, has been approved for the treatment of metastatic soft tissue sarcoma and ovarian cancers. MDMAs displayed potent activities that enabled them to be used as anticancer, anti-invasion, antimalarial, antiplasmodial, and antimicrobial. This review presents the reported chemical structures, biological activities, and structure–activity relationships of macrocyclic alkaloids from marine organisms that have been published since their discovery until May 2020. This includes 204 compounds that are categorized under eight subclasses: pyrroles, quinolines, bis-quinolizidines, bis-1-oxaquinolizidines, 3-alkylpiperidines, manzamines, 3-alkyl pyridinium salts, and motuporamines. MDPI 2020-07-17 /pmc/articles/PMC7404069/ /pubmed/32709048 http://dx.doi.org/10.3390/md18070368 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Althagbi, Hanan I. Alarif, Walied M. Al-Footy, Khalid O. Abdel-Lateff, Ahmed Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity |
title | Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity |
title_full | Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity |
title_fullStr | Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity |
title_full_unstemmed | Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity |
title_short | Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity |
title_sort | marine-derived macrocyclic alkaloids (mdmas): chemical and biological diversity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404069/ https://www.ncbi.nlm.nih.gov/pubmed/32709048 http://dx.doi.org/10.3390/md18070368 |
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