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Ferroptosis in Liver Diseases: An Overview
Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404091/ https://www.ncbi.nlm.nih.gov/pubmed/32664576 http://dx.doi.org/10.3390/ijms21144908 |
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author | Capelletti, Martina Maria Manceau, Hana Puy, Hervé Peoc’h, Katell |
author_facet | Capelletti, Martina Maria Manceau, Hana Puy, Hervé Peoc’h, Katell |
author_sort | Capelletti, Martina Maria |
collection | PubMed |
description | Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathione peroxidase 4 (GPX4), the presence of redox-active iron and the oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids are considered as distinct fingerprints of ferroptosis. Several pathways, including amino acid and iron metabolism, ferritinophagy, cell adhesion, p53, Keap1/Nrf2 and phospholipid biosynthesis, can modify susceptibility to ferroptosis. Through the decades, various diseases, including acute kidney injury; cancer; ischemia–reperfusion injury; and cardiovascular, neurodegenerative and hepatic disorders, have been associated with ferroptosis. In this review, we provide a comprehensive analysis of the main biological and biochemical mechanisms of ferroptosis and an overview of chemicals used as inducers and inhibitors. Then, we report the contribution of ferroptosis to the spectrum of liver diseases, acute or chronic. Finally, we discuss the use of ferroptosis as a therapeutic approach against hepatocellular carcinoma, the most common form of primary liver cancer. |
format | Online Article Text |
id | pubmed-7404091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74040912020-08-11 Ferroptosis in Liver Diseases: An Overview Capelletti, Martina Maria Manceau, Hana Puy, Hervé Peoc’h, Katell Int J Mol Sci Review Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathione peroxidase 4 (GPX4), the presence of redox-active iron and the oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids are considered as distinct fingerprints of ferroptosis. Several pathways, including amino acid and iron metabolism, ferritinophagy, cell adhesion, p53, Keap1/Nrf2 and phospholipid biosynthesis, can modify susceptibility to ferroptosis. Through the decades, various diseases, including acute kidney injury; cancer; ischemia–reperfusion injury; and cardiovascular, neurodegenerative and hepatic disorders, have been associated with ferroptosis. In this review, we provide a comprehensive analysis of the main biological and biochemical mechanisms of ferroptosis and an overview of chemicals used as inducers and inhibitors. Then, we report the contribution of ferroptosis to the spectrum of liver diseases, acute or chronic. Finally, we discuss the use of ferroptosis as a therapeutic approach against hepatocellular carcinoma, the most common form of primary liver cancer. MDPI 2020-07-11 /pmc/articles/PMC7404091/ /pubmed/32664576 http://dx.doi.org/10.3390/ijms21144908 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Capelletti, Martina Maria Manceau, Hana Puy, Hervé Peoc’h, Katell Ferroptosis in Liver Diseases: An Overview |
title | Ferroptosis in Liver Diseases: An Overview |
title_full | Ferroptosis in Liver Diseases: An Overview |
title_fullStr | Ferroptosis in Liver Diseases: An Overview |
title_full_unstemmed | Ferroptosis in Liver Diseases: An Overview |
title_short | Ferroptosis in Liver Diseases: An Overview |
title_sort | ferroptosis in liver diseases: an overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404091/ https://www.ncbi.nlm.nih.gov/pubmed/32664576 http://dx.doi.org/10.3390/ijms21144908 |
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