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Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control

Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retr...

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Autores principales: Khedr, Dina, Hafez, Mona, Lumpuy-Castillo, Jairo, Emam, Soha, Abdel-Massih, Antoine, Elmougy, Fatma, Elkaffas, Rasha, Mahillo-Fernández, Ignacio, Lorenzo, Oscar, Musa, Noha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404098/
https://www.ncbi.nlm.nih.gov/pubmed/32708413
http://dx.doi.org/10.3390/ijms21145079
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author Khedr, Dina
Hafez, Mona
Lumpuy-Castillo, Jairo
Emam, Soha
Abdel-Massih, Antoine
Elmougy, Fatma
Elkaffas, Rasha
Mahillo-Fernández, Ignacio
Lorenzo, Oscar
Musa, Noha
author_facet Khedr, Dina
Hafez, Mona
Lumpuy-Castillo, Jairo
Emam, Soha
Abdel-Massih, Antoine
Elmougy, Fatma
Elkaffas, Rasha
Mahillo-Fernández, Ignacio
Lorenzo, Oscar
Musa, Noha
author_sort Khedr, Dina
collection PubMed
description Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retrospectively examined. Glycemia, lipidemia, and albuminuria were measured in addition to development of cardiovascular abnormalities Both girls and boys showed higher HbA1c and fasting blood glucose and 27.1% females and 33.3% males exhibited microalbuminuria though their plasma levels of total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) and high-density lipoproteins (HDL lipoproteins were in the normal range. They exhibited a preserved systolic function, but 50% of females and 66.6% of males had developed diastolic failures. Interestingly, girls with diastolic dysfunction showed significantly lower concentrations of HDL and higher TC/HDL and TG/HDL ratios. In fact, low HDL levels (OR 0.93; 95% CI 0.88–0.99; p = 0.029) and high TC/HDL (OR 2.55; 95% CI 1.9–5.45; p = 0.016) and TG/HDL (OR 2.74; 95% CI 1.12–6.71; p = 0.028) ratios associated with the development of diastolic complications. The cut-off values for HDL, TC/HDL, and TG/HDL were 49 mg/dL, 3.0 and 1.85, respectively. HDL and TC/HDL and TG/HDL ratios may be useful for predicting diastolic dysfunction in girls with uncontrolled T1DM.
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spelling pubmed-74040982020-08-11 Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control Khedr, Dina Hafez, Mona Lumpuy-Castillo, Jairo Emam, Soha Abdel-Massih, Antoine Elmougy, Fatma Elkaffas, Rasha Mahillo-Fernández, Ignacio Lorenzo, Oscar Musa, Noha Int J Mol Sci Article Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retrospectively examined. Glycemia, lipidemia, and albuminuria were measured in addition to development of cardiovascular abnormalities Both girls and boys showed higher HbA1c and fasting blood glucose and 27.1% females and 33.3% males exhibited microalbuminuria though their plasma levels of total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) and high-density lipoproteins (HDL lipoproteins were in the normal range. They exhibited a preserved systolic function, but 50% of females and 66.6% of males had developed diastolic failures. Interestingly, girls with diastolic dysfunction showed significantly lower concentrations of HDL and higher TC/HDL and TG/HDL ratios. In fact, low HDL levels (OR 0.93; 95% CI 0.88–0.99; p = 0.029) and high TC/HDL (OR 2.55; 95% CI 1.9–5.45; p = 0.016) and TG/HDL (OR 2.74; 95% CI 1.12–6.71; p = 0.028) ratios associated with the development of diastolic complications. The cut-off values for HDL, TC/HDL, and TG/HDL were 49 mg/dL, 3.0 and 1.85, respectively. HDL and TC/HDL and TG/HDL ratios may be useful for predicting diastolic dysfunction in girls with uncontrolled T1DM. MDPI 2020-07-18 /pmc/articles/PMC7404098/ /pubmed/32708413 http://dx.doi.org/10.3390/ijms21145079 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khedr, Dina
Hafez, Mona
Lumpuy-Castillo, Jairo
Emam, Soha
Abdel-Massih, Antoine
Elmougy, Fatma
Elkaffas, Rasha
Mahillo-Fernández, Ignacio
Lorenzo, Oscar
Musa, Noha
Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control
title Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control
title_full Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control
title_fullStr Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control
title_full_unstemmed Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control
title_short Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control
title_sort lipid biomarkers as predictors of diastolic dysfunction in diabetes with poor glycemic control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404098/
https://www.ncbi.nlm.nih.gov/pubmed/32708413
http://dx.doi.org/10.3390/ijms21145079
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