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Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage

Cilia are cellular organelles that project from the cell. They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular...

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Autores principales: Barsch, Friedrich, Niedermair, Tanja, Mamilos, Andreas, Schmitt, Volker H., Grevenstein, David, Babel, Maximilian, Burgoyne, Thomas, Shoemark, Amelia, Brochhausen, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404129/
https://www.ncbi.nlm.nih.gov/pubmed/32674266
http://dx.doi.org/10.3390/ijms21144959
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author Barsch, Friedrich
Niedermair, Tanja
Mamilos, Andreas
Schmitt, Volker H.
Grevenstein, David
Babel, Maximilian
Burgoyne, Thomas
Shoemark, Amelia
Brochhausen, Christoph
author_facet Barsch, Friedrich
Niedermair, Tanja
Mamilos, Andreas
Schmitt, Volker H.
Grevenstein, David
Babel, Maximilian
Burgoyne, Thomas
Shoemark, Amelia
Brochhausen, Christoph
author_sort Barsch, Friedrich
collection PubMed
description Cilia are cellular organelles that project from the cell. They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular cartilage, primary cilia fulfil chemo- and mechanosensitive functions to adapt the cellular mechanisms on extracellular changes and thus, maintain tissue homeostasis and morphometry. Ciliary abnormalities in osteoarthritic cartilage could represent pathophysiological relationships between ciliary dysfunction and tissue deformation. Nevertheless, the molecular and pathophysiological relationships of ‘Primary Cilia’ (PC) in the context of osteoarthritis is not yet fully understood. The present review focuses on the current knowledge about PC and provide a short but not exhaustive overview of their role in cartilage.
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spelling pubmed-74041292020-08-11 Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage Barsch, Friedrich Niedermair, Tanja Mamilos, Andreas Schmitt, Volker H. Grevenstein, David Babel, Maximilian Burgoyne, Thomas Shoemark, Amelia Brochhausen, Christoph Int J Mol Sci Review Cilia are cellular organelles that project from the cell. They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular cartilage, primary cilia fulfil chemo- and mechanosensitive functions to adapt the cellular mechanisms on extracellular changes and thus, maintain tissue homeostasis and morphometry. Ciliary abnormalities in osteoarthritic cartilage could represent pathophysiological relationships between ciliary dysfunction and tissue deformation. Nevertheless, the molecular and pathophysiological relationships of ‘Primary Cilia’ (PC) in the context of osteoarthritis is not yet fully understood. The present review focuses on the current knowledge about PC and provide a short but not exhaustive overview of their role in cartilage. MDPI 2020-07-14 /pmc/articles/PMC7404129/ /pubmed/32674266 http://dx.doi.org/10.3390/ijms21144959 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barsch, Friedrich
Niedermair, Tanja
Mamilos, Andreas
Schmitt, Volker H.
Grevenstein, David
Babel, Maximilian
Burgoyne, Thomas
Shoemark, Amelia
Brochhausen, Christoph
Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
title Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
title_full Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
title_fullStr Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
title_full_unstemmed Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
title_short Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
title_sort physiological and pathophysiological aspects of primary cilia—a literature review with view on functional and structural relationships in cartilage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404129/
https://www.ncbi.nlm.nih.gov/pubmed/32674266
http://dx.doi.org/10.3390/ijms21144959
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