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Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2

A series of ten novel ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones bearing a 1-O-phosphono moiety and three different substituents at C-2 has been prepared. Due to the structural similarities of these scaffolds to the native substrate of mycobacterial galactofuranosyltransferase GlfT2 in the tra...

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Detalles Bibliográficos
Autores principales:	Baráth, Marek, Jakubčinová, Jana, Konyariková, Zuzana, Kozmon, Stanislav, Mikušová, Katarína, Bella, Maroš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2020
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404141/ https://www.ncbi.nlm.nih.gov/pubmed/32802202 http://dx.doi.org/10.3762/bjoc.16.152

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