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Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability
Nuclear β-dystroglycan (β-DG) is involved in the maintenance of nuclear architecture and function. Nonetheless, its relevance in defined nuclear processes remains to be determined. In this study we generated a C2C12 cell-based DG-null model using CRISPR-Cas9 technology to provide insights into the r...
Autores principales: | Jimenez-Gutierrez, Guadalupe Elizabeth, Mondragon-Gonzalez, Ricardo, Soto-Ponce, Luz Adriana, Gómez-Monsiváis, Wendy Lilián, García-Aguirre, Ian, Pacheco-Rivera, Ruth Abigail, Suárez-Sánchez, Rocío, Brancaccio, Andrea, Magaña, Jonathan Javier, C.R. Perlingeiro, Rita, Cisneros, Bulmaro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404207/ https://www.ncbi.nlm.nih.gov/pubmed/32674290 http://dx.doi.org/10.3390/ijms21144961 |
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