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Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA

Tryptase is a tetrameric serine protease located within the secretory granules of mast cells. In the secretory granules, tryptase is stored in complex with negatively charged heparin proteoglycans and it is known that heparin is essential for stabilizing the enzymatic activity of tryptase. However,...

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Detalles Bibliográficos
Autores principales: Alanazi, Sultan, Grujic, Mirjana, Lampinen, Maria, Rollman, Ola, Sommerhoff, Christian P., Pejler, Gunnar, Melo, Fabio Rabelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404274/
https://www.ncbi.nlm.nih.gov/pubmed/32709152
http://dx.doi.org/10.3390/ijms21145065

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