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Citalopram Administration Does Not Promote Function or Histological Recovery after Spinal Cord Injury

Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of bo...

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Detalles Bibliográficos
Autores principales: Lima, Rui, Monteiro, Susana, Gomes, Eduardo D., Vasconcelos, Natália L., Assunção-Silva, Rita, Morais, Mónica, Salgado, António J., Silva, Nuno A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404289/
https://www.ncbi.nlm.nih.gov/pubmed/32709070
http://dx.doi.org/10.3390/ijms21145062
Descripción
Sumario:Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week citalopram treatment in a contusive spinal cord injury (SCI) rat model. A combination of behavioral tests, histological and serum cytokine analysis was used to assess overall recovery. Despite promoting a mild reduction of inflammatory cells as well as an early, but transient increase of specific serum cytokines, citalopram administration showed no overall beneficial effects on motor performance or lesion extension. Our results do not support citalopram treatment as a therapeutic strategy for SCI.