Gram-scale synthesis of splat-shaped Ag–TiO(2) nanocomposites for enhanced antimicrobial properties

The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag–TiO(2) nanocomposites (NCs) were synthesized on the gram scale and the enhanced antibacterial properties of TiO(2) in the presence of silver were examined. The formation of Ag–TiO(2) NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO(2) NCs have good biocompatibility. The antibacterial activity of the prepared Ag–TiO(2) NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO(2) NCs exhibited promising and superior antibacterial properties compared to TiO(2) nanospheres as confirmed by the bacterial growth and inhibition zone. The improvement in the antibacterial activity was attributed to the synergistic effect of the hybrid nature of TiO(2) nanoparticles in the presence of Ag.