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Cardiomyopathies and Adrenal Diseases
Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural cardiomyocyte disorders due to adrenal diseases, such as hyperaldosteronism, hypercortisolism, and hypercatecholaminism, were misunderstood, and endomyocardial biopsy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404306/ https://www.ncbi.nlm.nih.gov/pubmed/32709015 http://dx.doi.org/10.3390/ijms21145047 |
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author | Petramala, Luigi Concistrè, Antonio Olmati, Federica Saracino, Vincenza Chimenti, Cristina Frustaci, Andrea Russo, Matteo A. Letizia, Claudio |
author_facet | Petramala, Luigi Concistrè, Antonio Olmati, Federica Saracino, Vincenza Chimenti, Cristina Frustaci, Andrea Russo, Matteo A. Letizia, Claudio |
author_sort | Petramala, Luigi |
collection | PubMed |
description | Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural cardiomyocyte disorders due to adrenal diseases, such as hyperaldosteronism, hypercortisolism, and hypercatecholaminism, were misunderstood, and endomyocardial biopsy (EMB) was not performed because was considered dangerous and too invasive. Recent data confirm that, if performed in experienced centers, EMB is a safe technique and gives precious information about physiopathological processes implied in clinical abnormalities in patients with different systemic disturbances. In this review, we illustrate the most important features in patients affected by primary aldosteronism (PA), Cushing’s syndrome (CS), and pheochromocytoma (PHEO). Then, we critically describe microscopic and ultrastructural aspects that have emerged from the newest EMB studies. In PA, the autonomous hypersecretion of aldosterone induces the alteration of ion and water homeostasis, intracellular vacuolization, and swelling; interstitial oedema could be a peculiar feature of myocardial toxicity. In CS, cardiomyocyte hypertrophy and myofibrillolysis could be related to higher expression of atrogin-1. Finally, in PHEO, the hypercontraction of myofilaments with the formation of contraction bands and occasional cellular necrosis has been observed. We expect to clear the role of EMB in patients with cardiomyopathies and adrenal disease, and we believe EMB is a valid tool to implement new management and therapies. |
format | Online Article Text |
id | pubmed-7404306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74043062020-08-18 Cardiomyopathies and Adrenal Diseases Petramala, Luigi Concistrè, Antonio Olmati, Federica Saracino, Vincenza Chimenti, Cristina Frustaci, Andrea Russo, Matteo A. Letizia, Claudio Int J Mol Sci Review Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural cardiomyocyte disorders due to adrenal diseases, such as hyperaldosteronism, hypercortisolism, and hypercatecholaminism, were misunderstood, and endomyocardial biopsy (EMB) was not performed because was considered dangerous and too invasive. Recent data confirm that, if performed in experienced centers, EMB is a safe technique and gives precious information about physiopathological processes implied in clinical abnormalities in patients with different systemic disturbances. In this review, we illustrate the most important features in patients affected by primary aldosteronism (PA), Cushing’s syndrome (CS), and pheochromocytoma (PHEO). Then, we critically describe microscopic and ultrastructural aspects that have emerged from the newest EMB studies. In PA, the autonomous hypersecretion of aldosterone induces the alteration of ion and water homeostasis, intracellular vacuolization, and swelling; interstitial oedema could be a peculiar feature of myocardial toxicity. In CS, cardiomyocyte hypertrophy and myofibrillolysis could be related to higher expression of atrogin-1. Finally, in PHEO, the hypercontraction of myofilaments with the formation of contraction bands and occasional cellular necrosis has been observed. We expect to clear the role of EMB in patients with cardiomyopathies and adrenal disease, and we believe EMB is a valid tool to implement new management and therapies. MDPI 2020-07-17 /pmc/articles/PMC7404306/ /pubmed/32709015 http://dx.doi.org/10.3390/ijms21145047 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Petramala, Luigi Concistrè, Antonio Olmati, Federica Saracino, Vincenza Chimenti, Cristina Frustaci, Andrea Russo, Matteo A. Letizia, Claudio Cardiomyopathies and Adrenal Diseases |
title | Cardiomyopathies and Adrenal Diseases |
title_full | Cardiomyopathies and Adrenal Diseases |
title_fullStr | Cardiomyopathies and Adrenal Diseases |
title_full_unstemmed | Cardiomyopathies and Adrenal Diseases |
title_short | Cardiomyopathies and Adrenal Diseases |
title_sort | cardiomyopathies and adrenal diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404306/ https://www.ncbi.nlm.nih.gov/pubmed/32709015 http://dx.doi.org/10.3390/ijms21145047 |
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