Inter-Regulation of K(v)4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies

Background: Genetic variants in voltage-gated sodium channels (Na(v)) encoded by SCNXA genes, responsible for I(Na), and K(v)4.3 channels encoded by KCND3, responsible for the transient outward current (I(to)), contribute to the manifestation of both Brugada syndrome (BrS) and spinocerebellar ataxia...

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Detalles Bibliográficos
Autores principales: Clatot, Jérôme, Neyroud, Nathalie, Cox, Robert, Souil, Charlotte, Huang, Jing, Guicheney, Pascale, Antzelevitch, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404392/
https://www.ncbi.nlm.nih.gov/pubmed/32709127
http://dx.doi.org/10.3390/ijms21145057

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