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The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis

The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to...

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Detalles Bibliográficos
Autores principales: Shin, Eunah, Koo, Ja Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404398/
https://www.ncbi.nlm.nih.gov/pubmed/32674405
http://dx.doi.org/10.3390/ijms21144967
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author Shin, Eunah
Koo, Ja Seung
author_facet Shin, Eunah
Koo, Ja Seung
author_sort Shin, Eunah
collection PubMed
description The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review.
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spelling pubmed-74043982020-08-18 The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis Shin, Eunah Koo, Ja Seung Int J Mol Sci Review The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review. MDPI 2020-07-14 /pmc/articles/PMC7404398/ /pubmed/32674405 http://dx.doi.org/10.3390/ijms21144967 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shin, Eunah
Koo, Ja Seung
The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis
title The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis
title_full The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis
title_fullStr The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis
title_full_unstemmed The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis
title_short The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis
title_sort role of adipokines and bone marrow adipocytes in breast cancer bone metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404398/
https://www.ncbi.nlm.nih.gov/pubmed/32674405
http://dx.doi.org/10.3390/ijms21144967
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