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The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis
The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404398/ https://www.ncbi.nlm.nih.gov/pubmed/32674405 http://dx.doi.org/10.3390/ijms21144967 |
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author | Shin, Eunah Koo, Ja Seung |
author_facet | Shin, Eunah Koo, Ja Seung |
author_sort | Shin, Eunah |
collection | PubMed |
description | The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review. |
format | Online Article Text |
id | pubmed-7404398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74043982020-08-18 The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis Shin, Eunah Koo, Ja Seung Int J Mol Sci Review The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review. MDPI 2020-07-14 /pmc/articles/PMC7404398/ /pubmed/32674405 http://dx.doi.org/10.3390/ijms21144967 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shin, Eunah Koo, Ja Seung The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis |
title | The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis |
title_full | The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis |
title_fullStr | The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis |
title_full_unstemmed | The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis |
title_short | The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis |
title_sort | role of adipokines and bone marrow adipocytes in breast cancer bone metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404398/ https://www.ncbi.nlm.nih.gov/pubmed/32674405 http://dx.doi.org/10.3390/ijms21144967 |
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